CORE--INSTRUMENTATION/SUPPORT FACILITY

核心设施旨在为该计划的所有或大多数参与者提供几个技术领域的支持。它提供核磁共振谱功能，可以方便地访问500、600和800 MHz仪器，使用Beckman XL-I超速离心机进行分析超速离心，傅立叶变换红外光谱分析，多肽合成，以及计算功能，包括三维结构显示、使用分子动力学模拟进行建模和数据库搜索。在两年多前启动赠款以来的一段时间里，这些设施中的每一个都已建成并进入运行状态。虽然要求进行一些可取的升级，但人们认为，核心基本上已经发展到很好的状态，如果配备适当的工作人员，它完全有能力支持下一个赠款期间拟议的研究。

The CORE facility is designed to provide support in several technical areas used by all or most of the participants in the program. It offers capabilities in NMR spectroscopy with facilitated access to 500, 600, and 800 MHz instruments, analytical ultracentrifugation using the Beckman XL-I ultracentrifuge, Fourier transform infrared spectroscopy, peptide synthesis, and computational capabilities that include three dimensional structural displays, modeling using molecular dynamics simulation, and database searching. In the period since the initiation of the grant a little more than two years ago, each of these facilities has been created and brought to operational status. While some desirable upgrades are requested, it is felt that the CORE has basically evolved to an excellent state, fully capable of supporting the research proposed for the next grant period if it is appropriately staffed.