SYNAPTIC PHYSIOLOGY OF NEOCORTICAL ECTOPIAS

新皮层上层神经元的异位聚集是 据推测，这会导致人类信息处理过程中的畸变， 和人类学习缺陷的小鼠模型。这些异位收集是 据信通过破坏适当的发展来发挥其影响 丘脑和新皮层回路的神经功能。的 在这个提议中描述的实验代表了第一个细胞 神经生理学分析的影响，新皮层异位， 皮层和丘脑的神经元。这些研究将由 全细胞膜片钳技术在活体脑神经元上的应用 从皮质异位的遗传小鼠模型、BXSB和 NZB小鼠，并且来自手术诱导的皮质异位模型。的 这些实验的目标是识别和表征畸变 与新皮质异位相关的突触和细胞生理学。 这一信息可能有助于深入了解细胞机制的基础 学习缺陷

Ectopic collections of neurons in upper layers of neocortex are hypothesized to cause aberrations in information processing in both humans and mouse models of human learning deficits. These ectopic collections are believed to exert their effects by disrupting the appropriate development of neuronal function in both thalamic and neocortical circuits. The experiments described in this proposal represent the first cellular neurophysiological analysis of the effects of neocortical ectopias on neurons in cortex and thalamus. These studies will be conducted by applying whole-cell patch clamp techniques to neurons in living brain slices obtained from genetic mouse models of cortical ectopias, BXSB and NZB mice, and from a surgically induced model of cortical ectopias. The goal of these experiments will be to identify and characterize aberrations in synaptic and cellular physiology associated with neocortical ectopias. This information may lend insight into the cellular mechanisms underlying learning deficits.