IMMUNE RESPONSE DURING MEASLES VIRUS INFECTION

描述(改编自调查者摘要)：麻疹仍然是主要的 世界性的健康问题。导致发病率的主要并发症 死亡是由继发感染和自身免疫性疾病引起的 感染后脑脊髓炎可能是由抑制作用引起的 麻疹病毒对免疫系统的影响。调查人员建议确定 麻疹免疫抑制的病毒和宿主决定因素 感染。要调查的领域与那些已经被 与免疫抑制的调节有关。具体目标是： 1)确定激活诱导的T细胞死亡是否作为一种 对麻疹病毒的免疫反应的后果；2)进一步确定 麻疹病毒免疫反应的2型性质；3)确定 麻疹病毒感染对基质上皮细胞功能的影响 细胞和麻疹感染胸腺基质细胞的机制 诱导胸腺细胞凋亡：4)确定麻疹病毒的作用 菌株对胸腺基质细胞转归及其分子生物学的影响 这些毒力差异的基础；5)确定免疫学 麻疹原发和继发常规免疫对儿童的影响 不同年龄儿童的免疫反应。

DESCRIPTION (Adapted from Investigator's abstract): Measles remains a major worldwide health problem. The primary complications leading to morbidity and mortality are caused by secondary infections and the autoimmune disease post-infectious encephalomyelitis likely caused by the suppressive effect of measles virus on the immune system. The investigators propose to identify the viral and host determinants of the immune suppression caused by measles infection. The areas to investigate are related to those that have been implicated in the regulation of immune suppression. The specific aims are: 1) to determine whether activation-induced T-cell death occurs as a consequence of the immune response to measles virus; 2) to determine further the type 2 nature of the immune response to measles virus; 3) to determine the effect of measles virus infection on the function of stromal epithelial cells and the mechanisms by which measles infection of thymic stromal cells induces apoptosis of thymocytes: 4) to determine the role of measles virus strain on the outcome of thymic stromal cells and the molecular and biologic basis of these differences in virulence; and 5) to determine the immunologic consequences of primary and secondary routine measles immunization on the immune responses of children of different ages.