URINE LOSS AND PROLAPSE IN NUNS AND THEIR PAROUS SISTERS

描述(由申请人提供)：本建议书是针对以下情况提交的 RFA：HD-O0-012，标题为“女性盆底流行病学研究” 尿失禁(UT)和盆腔器官脱垂(POP)是 老年妇女常见的健康问题，其原因很不清楚 明白了。阴道分娩时盆底的损伤和 遗传易感性被认为与尿崩症和尿崩症有关 波普。然而，这些关系的流行病学证据很少。 而且很有争议。我们对149名未分娩修女的调查研究数据发现 压力性尿失禁(S，UT)的患病率与#年报告的相同 临产的女人。我们建议的研究的主要目标是确定 阴道分娩和熟悉度是否与发育有关 尿失禁和盆腔器官脱垂的患病率比较 经客观证实的修女(未分娩妇女)大小便失禁和脱垂 在她们的亲生姐妹中，至少有过至少 一次阴道分娩。为了实现这一目标，我们将：招募修女的 至少有一次阴道分娩的亲生姐妹；收集数据 从修女和她们的姐妹那里了解到UT和POP的任何症状， 以及这些疾病的风险因素；并检查了修女和修女 寻找UT和POP的客观证据。主考人将被蒙在鼓里 受试者关于修女或姐妹的身份，以及有无 症状。有UT和POP症状或体征的女性将进一步接受 尿流动力学检查。最后，收集的数据将在匹配的 配对分析。我们将确定未分娩的修女是否与他们的 关于UT和POP的亲生姐妹。配对的逻辑关系 将执行回归以获得调整后的影响估计 UT和POP中的熟悉度和阴道分娩，考虑到其他风险 各种因素。

DESCRIPTION (provided by applicant): This proposal is submitted in response to RFA: HD-O0-012 entitled "Epidemiologic Research on Female Pelvic Floor Disorders." Urinary incontinence (UT) and pelvic organ prolapse (POP) are common health problems in older women, for which the etiologies are poorly understood. Injuries to the pelvic floor at the time of vaginal delivery and genetic predisposition have been implicated as factors associated with UT and POP. However, the epidemiological evidence for these relationships is scant and controversial. Our data from a survey study of 149 nulliparous nuns found the same prevalence of stress urinary incontinence (S UT) as was reported for parous women. The major objective of our proposed study is to determine whether vaginal delivery and familiality are associated with the development of urinary incontinence and pelvic organ prolapse by comparing the prevalence of objectively confirmed incontinence and prolapse in nuns (nulliparous women) with the corresponding rates in their biological sisters who have had at least one vaginal delivery. To achieve this objective, we will: recruit the nuns' biological sisters who have had at least one vaginal delivery; collect data from nuns and their sisters about the presence of any symptoms of UT and POP, and on any risk factors for these conditions; and examined nuns and sisters for objective evidence of UT and POP. The examiner will be blinded to the subjects' identity as to nun or sister, and to the presence or absence of symptoms. Women with signs or symptoms of UT and POP will undergo further urodynamic testing. Finally, the data collected will be tested in a matched pair analysis. We will determine whether nulliparous nuns differ from their biological sisters with regard to UT and POP. A matched pair logistic regression will be performed to obtain an adjusted estimate of the impact of familiality and vaginal delivery in UT and POP, taking into account other risk factors.