CORE--BIOSTATISTICS

生物统计学核心将：1)为研究设计、统计和遗传分析提供建议，包括样本量和功率计算。2)对人口和家庭数据进行统计分析，包括数据转换和调整。3)对群体和家庭数据进行遗传分析，包括：a)数量性状和定性疾病状况与遗传标记的两点和多点连锁分析；b)疾病状况和数量性状与遗传标记的家庭和群体关联检验。4)帮助解释分析结果，以确定研究计划的下一步。5)对小鼠杂交数据的实验设计和计算机分析提供建议。6)利用基因组数据库提供生物信息学支持，帮助构建EST序列，识别数据库中长序列的编码区。

The Biostatistics Core will: 1) Provide advice on research design and statistical and genetic analyses, including sample size and power calculations. 2) Conduct statistical analyses of population and family data, including data transformations and adjustments. 3) Conduct genetic analyses of population and family data, including: a) two-point and multi-point linkage analyses of quantitative traits and qualitative disease status with genetic markers, and b) family and population based tests of association of disease status and quantitative traits with genetic markers. 4) Aid in the interpretation of the results of analyses to identify the next steps in a research plan. 5) Provide advice on experimental design and computer analyses of data generated by murine crosses. 6) Provide Bioinformatics support in the use of genome databases to aid in the construction of EST contigs and the identification of the coding regions on long rage sequences in databases.