Nanocrystalline Coatings for Dental TMJ Implants

描述（由申请人提供）：物理系，牙科 口腔修复学与生物材料、口腔颌面部 UAB的外科提出了一个跨学科的计划来评估纳米晶体 用于牙科植入物的涂层。我们建议测试磨损的假设， 颞下颌关节植入物的骨固定特性 通过操纵纳米结构， 金刚石涂层（粘附和磨损）和羟基磷灰石涂层（固定）。 表面粗糙度仅为5-10 nm的纳米晶金刚石涂层将 通过微波等离子体化学气相沉积工艺制备， 甲烷/氢/氮物质。我们初步的粘附力和韧性 研究表明，高达150 kg的金刚石颗粒没有剪切破坏/松动 压痕载荷纳米晶磷酸钙（主要是羟基磷灰石） 涂层将通过脉冲激光沉积技术沉积在 螺钉和器械表面与骨接触。化学的精确控制 并且薄涂层的结构应该导致更优化的表面， 骨固定新的设计策略将实施统一 通过植入物在弯曲表面上的旋转和平移， 激活等离子体纳米金刚石和羟基磷灰石可以相互作用 在相同的植入物上，只要在高温下进行金刚石沉积， 首先，接着使用脉冲的羟基磷灰石的低温沉积， 激光纳米压痕研究将进行测量模量和 涂层的硬度以及在模拟牙科条件下的磨损测试。 纳米金刚石和钙的体内生物相容性测试 磷酸盐陶瓷将使用标准化模型系统进行， 包括微粒碎片以及软硬组织的注射 颗粒物和植入物的评价。体内部分将进行 与UAB的口腔颌面临床医生/外科医生合作， 积极参与颞下颌关节外科重建领域。

DESCRIPTION (provided by applicant): The Departments of Physics, Dental Prosthodontics and Biomaterials, and Department of Oral and Maxillofacial Surgery at UAB propose an interdisciplinary program to evaluate nanocrystalline coatings for dental implants. We propose to test the hypothesis that the wear and bone fixation characteristics of TMJ (temporomandibular joint) implant devices can be significantly improved by manipulation of the nanostructure of diamond coatings (adhesion and wear) and hydroxyapatite coatings (fixation). Nanocrystalline diamond coatings with surface roughness of only 5-10 nm will be produced by microwave plasma chemical vapor deposition process with methane/hydrogen/nitrogen species. Our preliminary adhesion and toughness studies have shown no shear failure/loosening of diamond particles up to 150 kg indentation load. Nanocrystalline calcium phosphate (primarily hydroxyapatite) coatings will be deposited by pulsed laser deposition techniques onto the screws and device surfaces in contact with bone. Precise control of chemistry and structure of the thin coating should result in a more optimum surface for fixation with bone. Novel design strategies will be implemented for uniform coating over curved surfaces by rotation and translation of the implant in the activated plasma. Nanostructured -diamond and -hydroxyapatite can be interfaced on the same implant, provided diamond deposition at high temperature is done first followed by a low temperature deposition of hydroxyapatite using pulsed lasers. Nanoindentation studies will be carried out to measure the modulus and hardness of coatings as well as wear testing under simulated dental conditions. In vivo biocompatibility testing of nanostructured diamond and calcium phosphate ceramics will be carried out using standardized model systems, including injection of particulate debris, plus soft and hard tissue evaluations of particulates and implants. The in vivo part will be carried out in collaboration with an oral and maxillofacial clinician/surgeon at UAB, who actively participates in the area of TMJ surgical reconstruction.