ONTOGENY OF METABOLIC CONTROLS OF INGESTIVE BEHAVIOR

产品说明： 从哺乳期到成年期的过渡是所有人面临的挑战 年轻的哺乳动物 在大鼠中，这种转变是在出生后几周内完成的， 了解幼鼠正常发育的机制 完全依靠大坝，完全独立的进水口调节 可以提供有价值的洞察力的干预失败，以实现 哺乳期到断奶期的转变。 在幼鼠的早期 生活中，调节摄入的生理信号似乎很少， 但在断奶前，幼崽开始调节它们的摄入量， 与能量代谢变化相关的信号。 这个实验 关于大鼠摄入调节发育的建议测试问题 利用这种代谢反应。 第一， 使用以下方法测试特定代谢燃料（脂肪）利用率的变化： 几种已知的抑制脂肪酸氧化的药理学试剂， 几个不同的生化步骤。 这些药剂的行为效应 与它们的生物化学效应进行比较，以测试利用率的变化 影响幼鼠的摄入量。 第二，因为生理信号 可以在许多行为水平上影响摄入， 代谢信号在其上发挥作用的行为成分， 发展被审查，以测试的机制，其中的变化， 能量的利用转化为摄食行为的变化。 此外，如果与能量利用的变化有关的信号 通常调节摄食，然后由代谢阻断剂诱导摄食 应类似于由能量限制引起的进食（即食物 剥夺）。 因此，类似的吸收前和吸收后生理信号 应抑制由食物剥夺和药物刺激的摄入 新陈代谢的阻滞。 这一假设是通过检查 抑制代谢阻断剂刺激的摄入的生理信号。 最后，神经机制参与翻译生理变化， 与能量利用相关的摄食行为增加， 测试.

DESCRIPTION: The transition from suckling to adult ingestion is a challenge facing all young mammals. In rats, this transition is made within weeks of birth and understanding the mechanisms by which rat pups normally develop from complete dependence on the dam to completely independent intake regulation may provide valuable insight for intervention in failures to accomplish the suckling to weaning transition in mammals in general. Early in a rat pup's life, the physiological signals which modulate ingestion appear to be few, but prior to weaning pups begin to modulate their intake in response to a signal related to changes in energy metabolism. The experiments in this proposal test questions about the development of intake regulation in rat pups using this emergent metabolic responsiveness. First, the role of changes in utilization of a specific metabolic fuel (fat) is tested using several pharmacological agents known to inhibit oxidation of fatty acids at several different biochemical steps. The behavioral effects of these agents are compared to their biochemical effects to test changes in the utilization of fats affect intake in young rats. Second, because physiological signals can affect ingestion at a number of behavioral levels, the ingestive behavioral components on which metabolic signals exert their effects during development is examined to test the mechanisms by which changes in the utilization of energy are translated into changes in ingestive behavior. Further, if a signal related to changes in the utilization of energy normally modulates ingestion, then feeding induced by metabolic blockers should be similar to feeding induced by energy restriction (i.e. food deprivation). Thus, similar pre- and post-absorptive physiological signals should suppress intake stimulated by food deprivation and pharmacological blockade of metabolism. This hypothesis is tested by examining the physiological signals suppressing intake stimulated by metabolic blockers. Finally, the neural mechanisms involved in translating physiological changes related to energy utilization into increases in ingestive behavior are tested.