GRADIENT UPGRADE ON 2T HUMAN MRI/MRS SYSTEM

在这项提案中，需要资金来升级2T人体磁共振成像(MRI)和光谱分析系统上的梯度组件。这块磁铁是代谢磁共振研究和计算中心(MMRRCC)的一部分，MMRRCC是由美国国立卫生研究院NCRR资助的地区性资源。目前，这种磁体的强度梯度约为0.5g/cm，不足以进行大多数最先进的磁共振波谱和成像实验。建议对梯度组件进行升级，以提供大约2.5G/cm的梯度强度。这种磁铁的一个独特特点是它有一个非常大的可用孔尺寸，这将使它能够执行涉及磁铁内练习的实验。除此之外，多核交叉获取、多核同时照射、动手脉冲编程能力等其他特征也大大有利于参与研究的人员的研究。这一工具将由五名独立调查人员共享，他们总共拥有七项NIH R01/R29拨款和一项P41。参与调查人员的研究领域涉及(A)肿瘤的诊断磁共振成像和波谱(B)关节炎的非侵入性诊断(C)肌肉功能的活体测量(D)心肌缺血成像和(E)区域资源的核心、合作和服务项目。

In this proposal funds are requested for upgrading gradient assembly on a 2T human magnetic resonance imaging(MRI) and spectroscopy system. This magnet is a part of the metabolic magnetic resonance research and computing center (MMRRCC), a regional resource funded by NCRR of NIH. Currently this magnet has a gradient of strength of approximately 0.5G/cm which is inadequate for performing most of the state of the art MR spectroscopy and imaging experiments. Gradient assembly is proposed to be upgraded to provide a gradient strength of approximately 2.5G/cm. One of the unique feature of this magnet is that it has a very large usable bore size which will enable to perform experiments involving in-magnet exercise. Along with this, other features such as multinuclear interleaved acquisition, simultaneous irradiation of multiple nuclei, hands-on pulse programming capabilities substantially benefit the research of the participating investigators. This instrument will be shared by five independent investigators who have a total of seven NIH R01/R29 grants and a P41. The research areas of participating investigators deal with (a) diagnostic MR imaging and spectroscopy of tumors (b) noninvasive diagnosis of arthritis (c) in vivo measurement of muscle function (d) imaging of myocardial ischemia and (e) core, collaborative and service projects of a regional resource.