LASER DOPPLER VELOCIMETER SYSTEM FOR BIOMEDICAL STUDIES

提交了一项拟议的共享仪器赠款（SIG），用于将现有的生物工程激光多普勒测速（LDV）系统升级为最先进的三组件光纤系统，包括多轴计算机控制的穿越能力。生物工程计划中现有的双组分系统已有17年的历史，并在此期间被广泛用于许多NIH资助的项目。目前的系统已经过时，并且由于制造商不再支持硬件而处于维修状态。拟议的设施将取代目前过时的系统，并升级生物工程的LDV能力。激光多普勒测速技术被认为是生物医学领域的金标准测速技术。因此，许多（包括NIH支持的）项目都依赖于生物工程计划的系统，以提供生物流体力学领域的准确流场定量。该SIG提案的具体目标是将生物工程的LDV系统升级为半便携式光纤系统（包括多轴和自动横移），该系统可以在需要生物流体机械测量的不同研究人员之间共享。该系统将结合目前最先进的信号处理器技术，光纤多功能性与多种接收能力。多轴横移系统将围绕基于光轨的系统进行设计，以提供横移硬件设置的多功能性。因此，每个研究人员都可以根据他们的流动环路几何形状定制穿越系统，并最大限度地提高效率和光学访问。该仪器设施将立即和未来用于研究，重点是血管工程，心血管流体力学，生物医学仪器技术，肺系统和细胞运输的流动相关的调查。该系统将为NIH资助的研究和NIH医疗超声换能器技术培训中心提供黄金标准的速度测量。该系统将成为正在进行的心血管假体研究的主要测量系统，包括机械心脏瓣膜空化和心室辅助装置。

A proposed Shared Instrument Grant (SIG) is submitted for a one-time award to upgrade the existing Bioengineering laser Doppler velocimetry (LDV) system to a state-of-the-art, three-component fiber optic system including multi-axis computer controlled traversing capabilities. The existing two-component system in the Bioengineering Program is 17 years old, and has been used extensively on numerous NIH funded projects throughout this period. The current system is outdated, and beyond a state of repair due to hardware no longer supported by the manufacturers. The proposed facility will replace the current obsolete system and upgrade Bioengineering's LDV capabilities. Laser Doppler velocimetry is considered to be the gold standard velocity measurement technique in the biomedical field. As a result, numerous (including NIH supported) projects have relied on the Bioengineering Program's system to provide accurate flow field quantitation in the area of bio-fluid mechanics. The specific aim of this SIG proposal is to upgrade Bioengineering's LDV system to a semi-portable, fiber-optic based system (including multiple-axes and automated traversing) that can be shared among the different investigators requiring bio-fluid mechanical measurements. The system will incorporate the current state-art-of-the-art in signal processor technology, fiber-optic versatility with multiple receiving capability. The multi-axis traversing system will be designed around an optical rail based system to provide versatility in traversing hardware set-up. Thus, each investigator can tailor the traversing system to their flow loop geometry and maximize efficiency and optical access. The instrumentation facility will find immediate and future use in studies focusing on vascular engineering, cardiovascular fluid mechanics, biomedical instrumentation technology, flow related investigations of the pulmonary system and cellular transport. The system will provide a gold standard velocity measurement for NIH funded research and the NIH training center for Medical Ultrasonic Transducer Technology. The system will be the primary measurement system for the ongoing research in cardiovascular prosthetics including mechanical heart valve cavitation and ventricular assist devices.