CORE--ANIMAL MODEL

本核心的目的是在不同的项目中提供一致的动物模型准备。为个体研究者准备慢性动物模型将是这个核心的责任。这将减少准备工作的可变性，并将个别项目主管从制作这些准备工作和照顾患者术后立即恢复的极度劳动密集型任务中解脱出来。各种动物模型将由Cornish博士或在他的指导下制备，他在慢性动物的制备方面有多年的经验，在这些特定的动物制剂方面经验丰富。我们将由两名技术人员协助准备和照顾动物，然后再由各调查人员使用。该核心制备的模型为：(1)大鼠心衰冠脉结扎模型，(1)家兔心衰起搏模型，(3)犬心衰起搏模型。

The purpose of this Core is to provide a consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for the individual investigators. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and care for their immediate post operative recovery. The various animal models will be prepared by or under the director of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. We will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, () the pacing model of HF in the rabbit, and (3) the pacing model of HF in the dog.