PATHOPHYSIOLOGY OF VESTIBULAR DISORDERS

该项目的目标是提高诊断和治疗 耳神经疾病患者。三个相互关联的方面 项目描述。调查人员将继续研究dizzy 将这些病例添加到其大型数据库中的患者。本研究 将在一系列测试中包括精确的计算机控制刺激， 测量前庭系统的各个方面。眼球运动和 在线采集和分析姿态数据。结果输入 数据库，并继续完善和查明新的 本项目正在进行头晕。在第二组实验中， 研究人员将对家族性周期性共济失调患者进行研究， 这种疾病与染色体19p上的一个区域有关。 将进行实验以缩小这一缺陷，可能到一个 钾通道障碍调查员收集了几个 有家族性疾病的家庭，并在临床上跟踪他们， 用分子生物学技术来评估它们。第三组 研究将把通过光学显微镜观察到的内部病理学 耳朵，神经和脑干的数据收集了几年， 临床实验室数据库中的患者。预计各国 8-10以前研究良好的患者将每年提供，作为一个 由于自然原因死亡的结果， 他们的前庭系统

The objective of this project is to improve diagnosis and treatment of patients with otoneurologic disorders. Three interrelated aspects of the projects are described. The investigators will continue to study dizzy patients with addition of these cases to their large database. This study will include precisely computer-controlled stimuli in a series of tests that measure various aspects of the vestibular systems. Eye movement and posture data are collected and analyzed on line. Results are entered into the database and continued refinement and identification of new cases of dizziness are ongoing in this project. In the second group of experiment, the investigators will study patients with familial periodic ataxia in which the disorder has been linked to a region on chromosome 19p. Experiments will be conducted to narrow this defect, possibly to a potassium channel disorder. The investigator's have collected several families with familial disorders and are following them clinically as well as evaluating them with molecular biology techniques. The third set of studies will correlate the pathology seen by light microscopy in the inner ear, nerve and brain stem with the data collected over several years on the patients in the clinical laboratory database. It is anticipated that 8-10 previously well studied patients will be available each year, as a result of death due to natural causes, for postmortem evaluations for their vestibular systems.