CLINICAL AND LABORATORY CORE

临床/实验室核心的牙科和医疗临床医生将查看旧金山流行病学队列转介的所有患者，并验证诊断。根据这些转介和其他患者转介来源，他们将继续建立特定口腔病变患者的临床队列，以分析他们与艾滋病发展和其他标志物/预测因素的关系。他们将为项目2、3和4中的研究获取活检和其他样本，这些样本来自具有良好特征的口腔病变患者。核心工作人员将负责临床研究患者记录、标本处理和存储，以及将标本送到项目2、3和4调查人员手中。他们将对涂片和切片进行染色，处理样本和活检组织样本，处理血液样本，维护病理和其他临床实验室数据，进行EB病毒的原位杂交，以确认毛状白斑的诊断。临床/实验室核心调查将继续研究艾滋病毒感染的口腔表现的临床和病理特征，并将与项目1、2、3和4的调查人员一起，继续报告新的特征，并探索其病因、发病机制、治疗反应和宿主对口腔病原体的免疫反应。核心和项目调查人员的部分责任将是继续记录和公布这些发现，并设想和测试关于这一令人着迷和具有挑战性的疾病组的新假设。

The dental and medical clinicians of the Clinical/Laboratory Core will see all patients referred by the San Francisco epidemiology cohorts and validate diagnoses. From these referrals and other sources of patient referrals, they will continue to build clinical cohorts of patients with specific oral lesions in order to analyze their relationship to the development of AIDS and to other markers/predictors. They will obtain biopsies and other samples for the studies in Projects 2, 3, and 4 from well-characterized patients with the oral lesions being studied. The core staff will be responsible for clinical research patient records, for specimen handling and storage and for getting specimens to Project 2, 3, and 4 investigators. They will stain smears and sections, handle samples and biopsy tissue specimens, process blood specimens, maintain pathology and other clinical laboratory data, perform in situ hybridization for Epstein-Barr virus to confirm the diagnosis of hairy leukoplakia. The Clinical/Laboratory Core investigates will continues will continue to study the clinical and pathological features of the oral manifestations of HIV infection and, in conjunction with Project 1, 2, 3, and 4 investigators, will continue to report new features and to explore their etiology, pathogenesis, responsive to therapy, and host immune response to oral pathogens. Part of the responsibilities of the investigators in the Cores and the Projects will be to continue to document and publish such findings and to conceive and test new hypothesis concerning this fascinating and challenging group of diseases.