COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
批准号:
6351291
负责人:
Duncan C. Thomas
金额:
$48.43万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-02-01 至 2004-01-31
中文摘要
在这项补助金中,我们建议集中进一步的工作在基因定位研究的计算问题,特别强调寻找基因的复杂性状相结合的连锁和连锁不平衡信息。 结合南加州大学(USC)和弗雷德哈钦森癌症研究中心(FHCRC)的研究力量,我们建议探索以下方法联合连锁和连锁不平衡分析:最大似然法使用经验模型的不平衡和群体遗传学模型的隔离和混合人口。用于半参数分析的有效估计方程(ESTA)方法MCMC方法适用于比目前可行的更大的谱系。
英文摘要
In this grant, we propose to focus further work on computational problems in gene mapping studies, with particular emphasis on finding genes for complex traits combining linkage and linkage disequilibrium information. Combining research forces at both the University of Southern California (USC) and the Fred Hutchinson Cancer Research Center (FHCRC), we propose to explore the following approaches for joint linkage and linkage disequilibrium analysis: Maximum likelihood methods using both empirical models for disequilibrium and population genetics models for isolated and admixed populations. Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible.
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专著(0)
科研奖励(0)
会议论文
Exogenous and Genetic Determinants of the Internal Environment
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批准号:9072859
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项目类别:
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资助金额:$26.88万
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财政年份:2016
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负责人:Duncan C. Thomas
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依托单位:
Statistical Methods for Epigenetic Mediation of Exposure-response Relations
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批准号:8600681
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项目类别:
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资助金额:$16.26万
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财政年份:2012
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负责人:Duncan C. Thomas
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依托单位:
Statistical Methods for Epigenetic Mediation of Exposure-response Relations
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批准号:8219246
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项目类别:
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资助金额:$16.35万
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财政年份:2012
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负责人:Duncan C. Thomas
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依托单位:
Statistical Methods for Epigenetic Mediation of Exposure-response Relations
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批准号:8416895
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项目类别:
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资助金额:$16.07万
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财政年份:2012
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负责人:Duncan C. Thomas
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依托单位:
Methods for Pathway Modeling with Application to Folate
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批准号:8255613
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项目类别:
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资助金额:$56.35万
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财政年份:2010
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负责人:Duncan C. Thomas
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依托单位:
Methods for Pathway Modeling with Application to Folate
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批准号:8129799
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项目类别:
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资助金额:$56.44万
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财政年份:2010
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负责人:Duncan C. Thomas
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依托单位:
Methods for Pathway Modeling with Application to Folate
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批准号:8450850
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项目类别:
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资助金额:$55.15万
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财政年份:2010
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负责人:Duncan C. Thomas
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依托单位:
Methods for Pathway Modeling with Application to Folate
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批准号:7990181
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项目类别:
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资助金额:$64.81万
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财政年份:2010
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负责人:Duncan C. Thomas
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依托单位:
Methods for Pathway Modeling with Application to Folate
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批准号:8651489
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项目类别:
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资助金额:$53.4万
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财政年份:2010
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负责人:Duncan C. Thomas
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依托单位:
DESIGN AND ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES
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批准号:7484280
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项目类别:
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资助金额:$30.25万
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财政年份:2006
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负责人:Duncan C. Thomas
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依托单位:
DESIGN AND ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES
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批准号:7280472
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项目类别:
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资助金额:$30.95万
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财政年份:2006
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负责人:Duncan C. Thomas
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依托单位:
DESIGN AND ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES
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批准号:7102896
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项目类别:
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资助金额:$31.53万
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财政年份:2006
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负责人:Duncan C. Thomas
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依托单位:
CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY
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批准号:6667476
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项目类别:
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资助金额:$11.79万
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财政年份:2002
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负责人:Duncan C. Thomas
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依托单位:
CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY
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批准号:6587868
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项目类别:
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资助金额:$11.79万
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财政年份:2002
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负责人:Duncan C. Thomas
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依托单位:
CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY
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批准号:6564410
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项目类别:
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资助金额:$11.79万
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财政年份:2001
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负责人:Duncan C. Thomas
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依托单位:
COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
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批准号:6052342
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项目类别:
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资助金额:$50.41万
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财政年份:2000
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负责人:Duncan C. Thomas
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依托单位:
CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY
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批准号:6347478
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项目类别:
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资助金额:$11.79万
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财政年份:2000
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负责人:Duncan C. Thomas
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依托单位:
CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY
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批准号:6301482
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项目类别:
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资助金额:$13.58万
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财政年份:2000
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负责人:Duncan C. Thomas
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依托单位:
COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
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批准号:6628874
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项目类别:
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资助金额:$50.31万
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财政年份:2000
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负责人:Duncan C. Thomas
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依托单位:
COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
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批准号:6498753
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项目类别:
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资助金额:$49.31万
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财政年份:2000
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负责人:Duncan C. Thomas
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依托单位:
海外基金