Sub voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging (small pixel camera)

该资助的知识交流项目旨在开发一种优化的碲化镉锌（CZT）系统，用于低剂量分子乳腺成像（MBI）。乳腺癌是英国最常见的癌症类型，每8名女性中就有1人患有这种疾病。约50%的筛查年龄妇女乳房密度较高，但传统的x线乳房x光检查降低了对这些患者的诊断效果。这一限制可以通过使用MBI来克服，MBI是一种分子示踪剂选择性靶向恶性乳腺组织以提供高分辨率功能图像的技术。使用优化的MBI系统进行早期诊断和更准确的疾病分期可能会改善患者的预后并降低死亡率。本研究将提高MBI的成像性能，提高乳腺病变的检出率。这将基于我们对辐射如何在成像系统中相互作用的了解。在这次新的呼叫中，将使用所要求的设备进行的额外研究将是探索使用这些技术提高医疗应用成像性能的可能性，如阿尔茨海默氏症和心脏病的诊断。

The funded knowledge exchange project seeks to develop an optimised Cadmium Zinc Telluride (CZT) system for low dose molecular breast imaging (MBI). Breast cancer is the most common type of cancer in the UK, with 1 in 8 women developing the disease. Approximately 50% of women of screening age have mammographically dense breasts but conventional X-ray mammography has reduced diagnostic performance for these patients. This limitation can be overcome by using MBI, a technique in which a molecular tracer selectively targets malignant breast tissue to provide high-resolution functional images. Earlier diagnosis and more accurate staging of the disease using optimised MBI systems will potentially lead to better patient outcomes and reduced mortality rates. The proposed research will improve the imaging performance of MBI, which will increase the probability of detecting lesions in the breast. This will be based on exploiting our knowledge of how radiation interacts in the imaging system. The additional research to be undertaken with the requested equipment in this new call will be to explore the possibility of using the techniques to enhance imaging performance for medical applications such as diagnosis of Alzheimer's and cardiac disease.