Treatment of cystic fibrosis with soy derived isoflavones

描述：研究人员建议开发一种含有染料木素和b-激动剂(支气管扩张剂)的气雾剂给药系统，用于治疗囊性纤维化(CF)。初步研究表明，金雀异黄素与CF跨膜电导调节因子相互作用，后者是由于特定突变而导致CF患者缺陷的。金雀异黄素提高了鼻膜的生物电势差(PD)，增加了氯的转运。这些研究人员致力于开发一种气雾剂，方法是评估染料木素改变帕金森的剂量和药代动力学，用该气雾剂进行重复剂量实验，最后用这种气雾剂进行安全性研究。最后一项研究将调查口服染料木素补充剂改变鼻膜PD的效果。

Description: The investigators propose to develop a aerosol delivery system containing genistein and a b-agonist (broncho-dilator) for the treatment of cystic fibrosis (CF). Preliminary studies have shown that genistein interacts with the CF transmembrane conductance regulator which is defective in patients with CF as a result of a specific mutation. Genistein raises the bioelectric potential differences (PD) across the nasal membrane and increases chloride transport. These investigators are directed at developing an aerosol by evaluating the dose and pharmacokinetics of genistein in regard to altering PD, performing a repetitive dose experiment with the aerosol, and finally performing safety studies with this aerosol. A final study will investigate the efficacy of using oral genistein supplements to alter the nasal membrane PD.