GENES OF HYPERTENSION IN AFRICAN AMERICANS

非裔美国人的高血压发病率高出近50%。 与高加索人相比，它与更高的发病率和 中风、心力衰竭和终末期肾病的死亡率。 研究旨在识别与高血压相关的基因。 以及与非裔美国人高血压相关的表型。 将使用全基因组搜索和候选基因方法。至 狭义的遗传异质性，我们将识别400个非裔美国人同胞 配对，年龄18-55岁，患有高血压，还 高胆固醇血症。其中200对同胞的广泛表型 将进行的是确定生理机制的遗传位点 这可能会导致高血压。表型研究将评估 肾功能、肾和外周血管反应性、胰岛素 敏感性和红细胞内的离子传输。以确定基因是否 被发现与高血压有关预测血液增加 压力，一个有患高血压风险的队列 (来自受影响的罪孽家族的正常血压的罪孽)将是基因 每3-4年重复测量血压。最后，DNA 将从150名血压正常、血脂正常的非裔美国人中收集 数量性状座位(QTL)的关联研究(病例对照) 在受影响的同胞对中发现了与高血压相关的基因 学习。

The incidence of hypertension in African Americans is nearly 50% higher than in Caucasians and is associated with higher rates of morbidity and mortality from stroke, heart failure, and end-stage renal disease. Studies are designed to identify genes that cosegregate with hypertension and with phenotypes associated with hypertension in African Americans. Both a genome wide search and a candidate gene approach will be used. To narrow genetic heteogeneity, we will identify 400 African American sib pairs, 18-55 years of age, who are hypertensive and also hypercholesterolemic. Extensive phenotyping of 200 of these sib pairs will be carried out to identify genetic loci of physiologic mechanisms that may contribute to hypertension. Phenotypic studies will evaluate renal function, renal and peripheral vascular reactivity, insulin sensitivity, and ion transport in erythrocytes. To determine if genes found to be associated with hypertension predict an increase of blood pressure, a cohort that is at risk for developing hypertension (normotensive sins from families of the 'affected' sins) will be genotype with repeat measurements of blood pressure in 3-4 years. Finally, DNA will be collected from 150 normotensive, normolipidemic African Americans for an association study (case control) for quantitative trait loci (QTL) which are found to cosegregate with hypertension in the affected sib pair study.