CORE--PHYSIOLOGY AND BIOCHEMISTRY LABORATORY

实验室核心旨在通过以下方式支持这五个项目 满足他们对生化和生理测量的需求 来识别它们的中间表型。种类繁多的化验 如果与盐敏性高血压密切相关，肾素- 血管紧张素-醛固酮轴，激肽系统，评估 高血压、肾脏灌注量和钠稳态的决定因素。全 核心中描述的技术和分析方法目前在 以核心为核心的实验室，以及专业和 实验室工作人员已经在扮演他们的角色方面进行了互动。这个 核心结构通过规模经济等实现成本节约 高效的资源分配、改进的质量控制和促进 协作。其他优势包括缩短周转时间 随着新的需求的出现，分析和更有效的适应。我们是 幸运的是，这个计划中的实验室核心不是一个构造 是为这个提议而发明的，而是一种当前的、活跃的资源，它 将能够以更高的效率在结构中发挥作用 由程序提供。我们也很幸运，所有的 这里描述的协作安排再一次不是 为这一提议而发明的构造，但反映了长期存在的 持续不断的关系。

The laboratory core is designed to support the five projects by satisfying their needs for the biochemical and physiological measurements that identify their intermediate phenotypes. The wide range of assays provided are germane to salt-sensitive hypertension, the renin- angiotensin-aldosterone axis, the kinin system, assessment of the determinants of hypertension, renal perfusion and sodium homeostasis. All of the techniques and assays described in the core are in current use in the laboratories encompassed by the core, and the professional and laboratory active personnel already interact in filling their roles. The core structure results in cost savings through economy of scale and more efficient resource allocation, improves quality control and facilitates collaboration. Additional advantages include reduced turnaround time on assays and more efficient adaptation as new demands arise. We are fortunate in that the laboratory core in this program is not a construct invented for this proposal, but rather a current, active resource which will be able to function with far greater efficiency in the structure provided by the program. We are also fortunate that all of the collaborative arrangements described herein, once again, are not a construct invented for this proposal but rather reflect longstanding and ongoing relationships.