RCMI CLINICAL RESEARCH INFRASTRUCTURE INITIATIVE

夏威夷大学（UH）的RCMI临床研究中心（CRC）的成功受到缺乏大学医院的挑战。因此，临床教员设在檀香山地区的几家社区医院，UH-RCMI-CRC设在一家Kapiolani医疗中心，这是一家专门的妇女和儿童设施。该临床研究中心的主要重点是促进临床研究的发展，重点是不成比例地影响夏威夷少数民族的医疗条件。UH-RCMI-CRC在过去四年中取得的显著成功突出体现在从主要社区医院招募了一批不同的研究人员，以及来自太平洋生物医学研究中心（PBRC）和夏威夷癌症研究中心（CRCH）的研究人员。自1995年9月成立以来，代表10个机构的99名研究人员在UH-RCMI-CRC进行了86项研究。 在这四年期间，UH-RCMI-CRC支持的研究人员出版了58本书的章节/评论，234篇摘要/演讲，195篇手稿，并获得了2300万美元的联邦拨款。此外，还完成了7份职业发展申请。其他提案已提交响应NIH RFA。为了进一步发展和扩大UH-RCMI-CRC，要求在另外5年的期限内继续提供支持，具体目标是取得GCRC地位。为了继续从UH医学院、PBRC和CRCH招募初级研究者，将继续优先重视方案制定。UH-RCMI-CRC还将继续协助有前途的调查人员申请职业发展奖。作为一项主要活动，研究基础设施和临床设施将扩大到包括在圣弗朗西斯医疗保健系统内的另一家主要医院的卫星中心。其他目标将是提供营养支持服务，扩大核心实验室的能力，包括分子生物学和脂质分析研究，并与佛蒙特大学-GCRC建立联系。为了支持与夏威夷人民相关的主要临床研究领域，UH-RCMI-CRC将促进四个卓越的临床研究领域。这些包括：艾滋病毒和新出现的病原体，新生儿/围产期研究，流行病学为基础的癌症研究，和夏威夷土著人的健康。UH-RCMI-CRC的研究工作将与新批准的临床研究卓越中心（CCRE）的活动无缝集成。最后，我们的研究工作将得到耶鲁大学医学院新任院长Edwin Cadman博士的帮助，他已正式同意将UH-RCMI-CRC指定为医学院的中央临床研究基础设施。

The success of the RCMI-Clinical Research Center (CRC) at the University of Hawaii (UH) has been challenged by the lack of a university hospital. Thus, the clinical faculty is based at several community hospitals in the Honolulu area with the UH-RCMI-CRC located at one, Kapiolani Medical Center, a specialty women's and children's facility. The major focus of this clinical research center is to foster the development of clinical research that focuses on medical conditions disproportionately affecting Hawaiian minorities. The remarkable success of the UH-RCMI-CRC over the last four years is highlighted by recruitment of a diverse group of investigators from the major community hospitals, as well as investigators from the PACIFIC Biomedical Research Center (PBRC) and the Cancer Research Center of Hawaii (CRCH). Since its inception in September 1995, 99 investigators representing 10 institutions have conducted 86 studies at the UH-RCMI- CRC. During this four-year period, UH-RCMI-CRC supported investigators have published 58 book chapters/reviews, 234 abstracts/presentations, 195 manuscripts, and have been award4ed 23 million dollars in federal grants. In addition, 7 career development applications have been completed. Other proposals have been submitted in response NIH RFAs. Continued support is requested for an additional 5-year term in order to further develop and expand develop and expand the UH-RCMI-CRC, with the specific goal of achieving GCRC status. In order to continue the recruitment of junior investigators from the UH School of Medicine, PBRC and CRCH, the emphasis on protocol development will continue to be a priority. The UH-RCMI-CRC will also continue to assist promising investigators in applying for career development awards. As a major activity, the research infrastructure and clinical facility will be expanded to include a satellite center at another major hospital within the St. Francis Healthcare System. Other goals will be provide nutritional support services, expand the capabilities of the core laboratory to include molecular biology and lipid analysis studies, and establish an affiliation with the University of Vermont-GCRC. In support of major areas of clinical research relevant to the peoples of Hawaii, the UH-RCMI-CRC will foster four areas of clinical research excellence. These include: HIV and Emerging Pathogens, Neonatal/Perinatal Research, Epidemiologic- based Cancer Research, and Native Hawaiian Health. The research efforts of the UH-RCMI-CRC will be seamlessly integrated with the activities of the newly approved Centers of Clinical Research Excellence (CCRE). Finally, our research efforts will be aided by the new Dean of the School of Medicine, Dr. Edwin Cadman from Yale University, who has formally agreed to designate the UH-RCMI-CRC as the central clinical research infrastructure for the School of Medicine.