CONST OF ANIMAL FACIL: ASTHMA

描述(由申请人提供)：本申请请求支持建造一个永久设施，用于安置、繁殖和照料转基因(转基因和基因敲除)和免疫受损的啮齿动物。该设施将位于由UTHSC-H正在设计的一座新的研究大楼内。UTHSC-H研究人员持有约1亿美元(总成本)的活跃的美国国立卫生研究院(NIH)-涉及动物的研究资金，以及每年700万美元的直接成本，用于正在进行的和正在进行的专门小鼠研究。热带风暴艾莉森完全摧毁了动物保护中心，该中心容纳了本研究中使用的大多数动物。不幸的是，数百只动物溺水身亡。为了防止这种情况再次发生，拟议中的设施将位于一座新的九层建筑的顶层。新大楼将与UTHSC-H医学院和分子医学研究所大楼建立封闭连接，以便支持所有三座大楼的调查人员的工作。拟建的设施面积为5945平方英尺。FT.，包括一个大型屏障套件，用于基因工程和免疫组成的啮齿动物。它将占据专门用于动物护理的大约半层楼，可容纳多达11,000只动物。该设施将由实验动物医学和护理中心(CLAMC)控制，该中心管理和运营UTHSC-H的所有动物护理和使用活动。CLAMC最初于1978年获得AAALAC国际认证，至今仍获得完全认证。CLAMC主任直接向UTHSC-H负责研究的执行副总裁报告。

DESCRIPTION (provided by applicant): This application requests support for construction of a permanent facility for housing, breeding and care of genetically engineered (transgenic and knockout) and immuno-compromised rodents. The facility will be located in a new research building being designed by the UTHSC-H. UTHSC-H Investigators hold approximately $100 million (total costs) of active National Institutes of Health (NIH)-funding for studies involving animals, and $7 million in yearly direct costs for active and pending studies with specialized mice. Tropical Storm Allison totally destroyed the Animal Care Center that housed most of the animals used for this research. Tragically, hundreds of animals drowned. To prevent this from ever happening again, the proposed facility will be on the top floor of a new nine-story building. The new building will have enclosed connections to the UTHSC-H Medical School and Institute for Molecular Medicine Buildings, so that it will support the work of investigators in all three buildings. The proposed facility will contain 5,945 sq. ft., including a large barrier suite, for genetically engineered and immuno-comprised rodents. It will occupy roughly half a floor devoted exclusively to animal care and accommodate up to 11,000 animals. The facility will be under the control of the Center for Laboratory Animal Medicine and Care (CLAMC), which manages and operates all animal care and use activities at the UTHSC-H. The CLAMC was initially accredited by the AAALAC International in 1978 and remains fully accredited today. The Director of the CLAMC reports directly to the Executive Vice President for Research of the UTHSC-H.