CONST OF ANIMAL FACIL: TUBERCULOSIS

描述（由申请人提供）：本申请要求支持建设一个永久性设施，用于住房，繁殖和照顾基因工程（转基因和敲除）和免疫受损的啮齿动物。该设施将位于由UTHSC-H设计的新研究大楼中。UTHSC-H研究人员拥有大约1亿美元（总费用）的美国国立卫生研究院（NIH）的活跃资金，用于动物研究，每年700万美元的直接费用用于正在进行的和正在进行的专门小鼠研究。热带风暴艾利森彻底摧毁了动物护理中心，该中心饲养了用于这项研究的大多数动物。不幸的是，数百只动物淹死了。为了防止这种情况再次发生，拟议中的设施将设在一座新九层建筑的顶层。新大楼将与UTHSC-H医学院和分子医学研究所大楼有封闭的连接，因此它将支持所有三座大楼的研究人员的工作。拟议的设施将占地5945平方米。包括一个大型屏障套件，用于基因工程和免疫组成的啮齿动物。它将占据大约半层楼，专门用于动物护理，最多可容纳11,000只动物。该设施将由实验动物医学和护理中心（CLAMC）控制，该中心负责管理和运营UTHSC-H的所有动物护理和使用活动。该中心最初于1978年获得AAALAC国际认证，至今仍完全获得认证。中心主任直接向研究部常务副院长汇报工作。

DESCRIPTION (provided by applicant): This application requests support for construction of a permanent facility for housing, breeding and care of genetically engineered (transgenic and knockout) and immuno-compromised rodents. The facility will be located in a new research building being designed by the UTHSC-H. UTHSC-H Investigators hold approximately $100 million (total costs) of active National Institutes of Health (NIH)-funding for studies involving animals, and $7 million in yearly direct costs for active and pending studies with specialized mice. Tropical Storm Allison totally destroyed the Animal Care Center that housed most of the animals used for this research. Tragically, hundreds of animals drowned. To prevent this from ever happening again, the proposed facility will be on the top floor of a new nine-story building. The new building will have enclosed connections to the UTHSC-H Medical School and Institute for Molecular Medicine Buildings, so that it will support the work of investigators in all three buildings. The proposed facility will contain 5,945 sq. ft., including a large barrier suite, for genetically engineered and immuno-comprised rodents. It will occupy roughly half a floor devoted exclusively to animal care and accommodate up to 11,000 animals. The facility will be under the control of the Center for Laboratory Animal Medicine and Care (CLAMC), which manages and operates all animal care and use activities at the UTHSC-H. The CLAMC was initially accredited by the AAALAC International in 1978 and remains fully accredited today. The Director of the CLAMC reports directly to the Executive Vice President for Research of the UTHSC-H.