RENOV OF BIOCHEM FACIL: CHOLERAE

描述(由申请人提供)：申请资金翻新15,890平方米。英国《金融时报》位于密歇根大学校园的化学和生物化学大楼的研究空间和外壳空间。翻修将包括分析、合成和生物化学湿实验室区域和实验室支助空间、研究办公室、共享仪表室以及玻璃车间的扩建和升级。最初的建筑于1970年入驻，目前正在进行重大的首都翻修。此应用程序中的空间不包括在此项目中。根据教学和研究方法的改变，使用设施更新资金，并根据需要对这些学校进行了翻新。实验室的设计从来没有从整个设施的角度来考虑。长椅摆放得很随意，几乎没有灵活性。公共设施目前是在空间允许的范围内，使得区域不是最优的。尽管该学院的大部分教员都从事生物化学工作，但大楼里只有一张干净的长凳，没有适当的组织培养设施。体外研究在匹兹堡大学、国家过敏和传染病研究所(NAAD)、国家心肺和血液研究所(NHLBI)或UMBC的实验室进行。这一翻新的长期目标是将这些区域与正在翻新的中央系统联系起来，提供位于中心的组织培养和共享设施，以及为系系提供灵活的实验室单元。这一领域的研究将集中在抗肿瘤和抗病毒药物的开发、致癌机制和紧急输血的携氧血液替代品上。

DESCRIPTION (provided by applicant): Funds are requested to renovate 15,890 sq. ft. of research space and shell space in the Chemistry and Biochemistry Building on the campus of the UMBC. The renovation will consist of Analytical, Synthetic and Biochemistry wet laboratory areas and laboratory support space, research offices, shared instrument rooms and the enlargement and upgrade of glass shop. The original building, occupied in 1970, is currently under a major capital renovation. The spaces in this application are not included in this project. They have been renovated "as needed" using facility renewal funds and as dictated by changing teaching and research methods. The design of the laboratories was never thought out in respect to the facility as a whole. Benches are laid out haphazardly, with little or no flexibility. Common use facilities are currently where space permitted, making the areas less than optimal. Although a vast number of the Faculty are involved in Biochemistry, there is a single clean bench in the building, no proper tissue culture facilities. In vitro studies are carried out in laboratories at the University of Pittsburgh, National Institute of Allergy and Infectious Diseases (NAIAD); National Heart, Lung and Blood Institute (NHLBI) or the UMBC. The long-term objective of this renovation is to tie these areas into the central systems being renovated, provide centrally located tissue culture and shared facilities, along with flexible laboratory modules for the Department Faculty. Research in this space will focus on the development of antineoplastic and antiviral drugs, mechanisms of carcinogenesis and oxygen carrying blood substitutes for emergency transfusions.