MAGNETIC RESONNANCE CTR:STRUCTURE, FUNCTION OF HIV-1 VPR & HHR23A

关于艾滋病：说明（由申请人提供）：申请资金用于建造一个1300平方米的建筑。位于加州大学洛杉矶分校分子楼一楼，与现有仪器设备相邻的核磁共振大楼。该建筑将用于容纳高场核磁共振光谱仪（600 MHz和MHz）。现有的仪器实验室没有空间容纳新的600兆赫的高场光谱仪，即使目前的仪器可以重新安置，也没有足够的空间容纳800兆赫的光谱仪。因此，这座建筑对于加州大学洛杉矶分校核磁共振设施的扩展至关重要，这是支持医学和生物化学前沿的生物医学研究人员所需要的。该设施的独特之处在于将物理化学家、有机化学家、结构生物学家、生命科学家和医学院的教师聚集在一起，利用核磁共振波谱技术解决问题。将受益于核磁共振资源的具体研究领域是蛋白质、核酸和复合物的结构生物学、大分子相互作用和动力学、结构基因组学、合成有机分子的表征、大分子组装和天然产物，以及生物分子成像。

Regarding AIDS: DESCRIPTION (provided by applicant): Funds are requested for the construction of a 1,300 sq. ft. NMR building adjacent to the current instrumentation facilities on the first floor of the Molecular S Building at UCLA. This building will be used to house high field NMR spectrometers (600 MHz an MHz). There is no room in the existing instrumentation laboratories to house new high field spectrometer at 600 MHz and no adequate space to house an 800 MHz spectrometer even if current instrumentation could be relocated. Thus, this building is essential for the expansion of NMR facilities at UCLA, which is needed to support biomedical researchers at the forefront of medicine and biochemistry. This facility will be unique in bringing together physical chemists, organic chemists, structural biologists, life scientists, and faculty in the school of medicine to solve problems using NMR spectroscopy. Specific research areas that will benefit from the NMR Resource are structural biology of proteins, nucleic acids, and complexes, macromolecular interactions and dynamics, structural genomics, characterization of synthetic organic molecules, macromolecular assemblies, and natural products, and biomolecular imaging.