RENOV OF BIOCHEM FACIL: HIV I RNA PACKAGING FOR DEVELOPMENT OF LESS TOXIC DRUGS

关于艾滋病：描述（由申请人提供）：需要资金翻新15,890平方米。在UMBC校园的化学和生物化学大楼里，有一英尺的研究空间和外壳空间。改造将包括分析、合成和生物化学湿实验室区域和实验室支持空间、研究办公室、共享仪器室以及玻璃店的扩大和升级。原来的建筑建于1970年，目前正在进行重大的首都翻新。此应用程序中的空格不包括在此项目中。这些学校“根据需要”使用设施更新资金，并根据教学和研究方法的变化进行了翻新。实验室的设计从来没有考虑过整个设施。长椅随意摆放，几乎没有灵活性。公共设施目前在空间允许的情况下，使得区域不太理想。虽然很多教员都在研究生物化学，但教学楼里只有一张干净的长凳，没有合适的组织培养设备。体外研究在匹兹堡大学国家过敏和传染病研究所（NAIAD）的实验室进行；国家心脏，肺和血液研究所（NHLBI）或UMBC。这次改造的长期目标是将这些区域与正在改造的中央系统联系起来，提供集中的组织培养和共享设施，以及为院系提供灵活的实验室模块。该领域的研究将集中在抗肿瘤和抗病毒药物的开发，致癌机制和紧急输血的含氧血液替代品。

Regarding AIDS: DESCRIPTION (provided by applicant): Funds are requested to renovate 15,890 sq. ft. of research space and shell space in the Chemistry and Biochemistry Building on the campus of the UMBC. The renovation will consist of Analytical, Synthetic and Biochemistry wet laboratory areas and laboratory support space, research offices, shared instrument rooms and the enlargement and upgrade of glass shop. The original building, occupied in 1970, is currently under a major capital renovation. The spaces in this application are not included in this project. They have been renovated "as needed" using facility renewal funds and as dictated by changing teaching and research methods. The design of the laboratories was never thought out in respect to the facility as a whole. Benches are laid out haphazardly, with little or no flexibility. Common use facilities are currently where space permitted, making the areas less than optimal. Although a vast number of the Faculty are involved in Biochemistry, there is a single clean bench in the building, no proper tissue culture facilities. In vitro studies are carried out in laboratories at the University of Pittsburgh, National Institute of Allergy and Infectious Diseases (NAIAD); National Heart, Lung and Blood Institute (NHLBI) or the UMBC. The long-term objective of this renovation is to tie these areas into the central systems being renovated, provide centrally located tissue culture and shared facilities, along with flexible laboratory modules for the Department Faculty. Research in this space will focus on the development of antineoplastic and antiviral drugs, mechanisms of carcinogenesis and oxygen carrying blood substitutes for emergency transfusions.