RES BLDG RENOVATION: CANCER

描述(由申请人提供)：谢彭斯眼科研究所打算翻新其64,000平方米的面积。英国《金融时报》实验室建筑大约建于40年前。该计划的目标是提供现代实验室和辅助设施，使个别科学家能够单独和合作，用强大的现代科学学科来解决目前尚不存在预防或治愈的疾病病理学问题。翻新计划包括两个阶段；第一阶段正在进行中，旨在重建建筑的基础设施供暖、通风和空调(HVAC)、管道和电力系统等。第二阶段旨在翻新三个实验室楼层(16,000平方米。英国《金融时报》每个)在三个连续的段中。第一和第二部分是2000年资助的上一次申请的主题，其目标是为14名首席调查员(PI)在三个不同的楼层翻新实验室，开展眼睛免疫、炎症和移植(二楼北)、眼表疾病(三楼)和视网膜生物学(一楼北)的研究活动。3a段是本申请的主题，其目标是翻新约10,000平方英尺。英国《金融时报》在实验室大楼南侧的二层空间，以便为四个研究重点是眼睛免疫、炎症和移植的个人投资机构提供高质量的实验室。完成后，研究所所有从事免疫、炎症和移植工作的研究人员将位于二楼。此外，翻新后的区域将包括：1)新的分子生物学核心设施；2)玻璃器皿清洗设施；3)会议室和交流中心。3a段的总费用为390万美元，请拨约180万美元。一旦完成了3a段，将有空间进行3b段。在翻新计划完成后，研究所将拥有一个足以满足目前研究需要的物理设施。

DESCRIPTION (Provided by applicant): The Schepens Eye Research Institute intends to renovate its 64,000 sq. ft. laboratory building built approximately 40 years ago. The goal of this program is to provide modern laboratories and support facilities to enable individual scientists, alone and in collaborations, to attack with powerful modern scientific disciplines the problems of disease pathology for which no prevention or cure now exists. The renovation program consists of two phases; the first of which is underway and is designed to reconstruct the building's infrastructure heating, ventilation, and air-conditioning (HVAC); plumbing; and electricity systems; etc. The second phase is designed to renovate the three laboratory floors (16,000 sq. ft. each) in three sequential segments. Segments one and two, which were the subject of the previous application that was funded in 2000, had the goal of renovating laboratories on three separate floors for 14 Principal Investigators (PIs) with research activities in ocular immunity, inflammation and transplantation (Second Floor North), ocular surface diseases (Third Floor), and biology of the retina (First Floor North). Segment 3a, which is the subject of the current application, has the goal of renovating approximately 10,000 sq. ft. of space on the second floor South of laboratory building in order to provide high quality laboratories for four PIs whose research focus is ocular immunity, inflammation and transplantation. Upon completion, all investigators at the Institute working in immunity, inflammation and transplantation will be located on the second floor. In addition, the renovated area will include: 1) a new molecular biology core facility; 2) a glassware washing facility; and 3) a conference room and communication center. Approximately $1.8 million toward a total cost of $3.9 million for Segment 3a is requested. Once Segment 3a is accomplished, space will be available to carry out Segment 3b. At the completion of the renovation program, the Institute will have a physical facility sufficient to meet present research needs.