ROSWELL PARK DNA REPLICATION PROG FACIL: ANTITUMOR DRUG

描述(由申请人提供)：RPCI即将完成一项重大的现代化计划，该计划将在2002年之前取代或翻新其25英亩校园内的几乎所有建筑。最近的建设使细胞和病毒大楼中的大量空间得以腾出，为癌症遗传学中心的扩建做准备。许多留在这栋大楼里的研究人员都是DNA复制计划的成员，该计划是癌症遗传学中心不可或缺的组成部分。这个高度互动的科学家小组的研究重点是与癌症问题相交的DNA复制方面，以及如何有效地治疗这种疾病。这一独特的计划利用了RPCI和布法罗地区其他学术机构在DNA复制领域不同寻常的大量专业知识。本申请申请的资金将用于翻新六层细胞和病毒大楼的二楼和三楼，供这些调查人员使用，他们的项目现在位于四个不同的楼层。随着2000年约翰·考威尔博士被任命为癌症遗传学系主任，预计将有另外四名新成员加入这一计划。将计划成员的研究活动合并到毗连的空间将促进合作，并允许用其他资金翻新大楼的剩余楼层，最终为扩大的癌症遗传学中心提供实验室空间。

DESCRIPTION (Provided by applicant): RPCI is nearing completion of a major modernization program that will replace or renovate nearly all the buildings on its 25-acre campus by the year 2002. Recent construction has made it possible to vacate a large amount of space in the Cell and Virus Building in preparation for the expansion of the Center for Cancer Genetics. Many of the investigators who remain in this building are members of the DNA Replication Program, which is an integral component of the Center for Cancer Genetics. The research focus of this highly interactive group of scientists is on aspects of DNA replication that intersect with the problem of cancer and how to effectively treat this disease. This unique program capitalizes on the unusually large amount of expertise in the field of DNA replication at RPCI and other academic institutions in the Buffalo area. The funds requested in this application will be used to renovate the second and third floors of the six-story Cell and Virus Building for occupancy by these investigators, whose programs are now housed on four different floors. With the appointment of John Cowell, Ph.D., as Chair of the Department of Cancer Genetics in 2000, an additional four recruits are anticipated into this program. Consolidation of the research activities of Program members into contiguous space will facilitate collaborations and allow for the renovation of the remaining floors of the building with other funds to eventually provide laboratory space for the expanded Center for Cancer Genetics.