ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANS

这项研究专门针对测定大豆食品和配方中大量含有的异黄酮类非甾体雌激素化合物在人体内的生物利用度和药代动力学。这些具有生物活性的非营养素在动物身上的新陈代谢已经得到了广泛的研究，但在人类身上的信息有限。尽管我们之前已经确定了可以在女性身上引发生物反应的饮食摄入量水平，但对于不同食物或配方中异黄酮的生物利用度、个体之间是否存在很大差异、性别或年龄相关的吸收或代谢差异以及是否存在剂量反应效应，我们知之甚少。为此，我们将测定不同食物和配方中所含大豆异黄酮类的生物利用度和药代动力学。

This study is specifically directed at determining in humans, the bioavailability and pharmacokinetics of isoflavones, non-steroidal estrogenic compounds, contained in abundance in soy foods and formulas. The metabolism of these bioactive non-nutrients has been extensively studied in animals, but information in humans is limited. Although we have previously established a level of dietary intake that can invoke a biological response in women, little is known about the bioavailability of isoflavones from different foods or formulas, whether there are large variations among individuals, or gender or age-related differences in absorption or metabolism, and if there are dose-response effects. To this end, we will be determining the bioavailability and pharmacokinetics of soy isoflavones contained in different kinds of foods and formulas.