EVALUATION & REDUCTION OF RISK FACTORS FOR CARDIOVASCULAR DISEASE (OB

降低风险因素已成为心血管疾病（CLD）预防/治疗的可接受方法。 临床试验的结果已经证明了该领域的计划在减少尺寸，血压，血糖和血脂方面的有效性。 本研究将通过一组年龄在13-75岁的任何种族背景的至少50名女性和40名男性达到以下目的，其中至少肥胖是一个CLD风险因素：1）确定专门设计的、文化敏感的生活方式改变计划在降低CLD风险中的有效性; 2）证明脂肪改良饮食在降低血脂和血糖、血压和体型方面的可行性，3）检查运动与血脂组分，特别是HDL之间的关系。采用前瞻性研究设计，受试者接受医疗和饮食数据的基线测量。 这个基线期之后是筛选，为期八个月的密集干预和干预后阶段。常规随访检查研究人群中CVD危险因素的顺序变化发生在干预后期间。 假设具有一个或多个CVD风险因素的受试者采用更健康的生活方式（包括脂肪改良饮食、运动、行为改变、戒烟），将证明CVD发展的风险因素特征得到改善。

Risk factor reduction has become an acceptable approach to cardiovascular disease (CLD) prevention/treatment. The results of clinical trials have demonstrated the effectiveness of programs in this area in reducing size, blood pressure, and serum glucose and lipids. This study will meet the following objectives through a cohort of at least 50 women and 40 men of any ethnic background, ages 13-75 years, with at least obesity as one CLD risk factor: 1) Determine the effectiveness of a specially-designed, culturally sensitive lifestyle change program in CLD risk reduction; 2) Demonstrate the feasibility of a fat-modified diet in reducing serum lipids and glucose, blood pressure, and body size, and 3) Examine the relationship between exercise and serum lipid fractions, particularly HDL. Using a prospective study design, subjects undergo baseline measurements of medical and dietary data. This baseline period is followed by screening, an intense eight-month intervention, and post intervention periods. Routine followup to examine sequential changes in CVD risk factors in the study population takes place during the post intervention period. It is hypothesized that subjects who have one or more CVD risk factors who adopt healthier lifestyles (including a fat-modified diet, exercise, behavior modification, smoking cessation) will demonstrate an improved risk factor profile for the development of CVD.