课题基金 / 基金详情

MECHANISM UNDERLYING PARENTERAL INSULIN TREATMENT

MECHANISM UNDERLYING PARENTERAL INSULIN TREATMENT
肠外胰岛素治疗的潜在机制
批准号：
6368077
负责人：
JERRY P PALMER
金额：
$0.39万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6368077
关键词：
clinical research disease /disorder prevention /control disease /disorder proneness /risk hormone regulation /control mechanism hormone therapy human subject human therapy evaluation insulin insulin dependent diabetes mellitus intravenous administration pancreatic islet function

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中文摘要
翻译
DPT-1是一项多中心、随机、全国性试验，旨在确定对高危非糖尿病个体进行基于抗原的治疗是否可以预防继发性IDDM。 胰岛素IV给药4天，然后皮下注射至随机分配至治疗组的受试者。待检验的基本假设是，在DPT-1中，通过胃肠外给药胰岛素对临床IDDM高风险受试者的保护作用至少部分是通过胰岛素抑制b细胞功能（β细胞静息）的代谢作用介导的。了解肠外胰岛素预防胰岛素依赖型糖尿病的机制将为今后开发更好的预防方法提供基础。
英文摘要
The DPT-1 is a multi-centered, randomized, national trial designed to determine whether antigen based therapy of high risk nondiabetic individuals can prevent subsequent IDDM. Insulin is administered IV for 4 days and then subcutaneously to those randomized to the treatment arm. The underlying hypothesis to be tested is that protection against clinical IDDM achieved by parenteral administration of insulin to subjects at high risk of clinical IDDM in the DPT-1 is mediated, at least in part, by insulin's metabolic effect to inhibit b-cell function (beta cell rest). Understanding the mechanism whereby parenteral insulin prevents IDDM would provide the basis for improved methods of prevention to be developed in the future.
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Ancillary Study Proposal for The Restoring Insulin Secretion (RISE) Study: Autoimmune Mechanisms for the Progressive Decline of Beta cell Function in Type 2 Diabetes (T2D)
Ancillary Study Proposal for The Restoring Insulin Secretion (RISE) Study: Autoimmune Mechanisms for the Progressive Decline of Beta cell Function in Type 2 Diabetes (T2D)
Identification of Islet Proteins Stimulatory for T Cells from Diabetes Patients
  • 批准号：
    8217176
  • 项目类别：
  • 资助金额：
    $36.43万
  • 财政年份：
    2010
  • 负责人：
    JERRY P PALMER
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Identification of Islet Proteins Stimulatory for T Cells from Diabetes Patients
  • 批准号：
    7780170
  • 项目类别：
  • 资助金额：
    $46.08万
  • 财政年份：
    2010
  • 负责人：
    JERRY P PALMER
  • 依托单位：
    UNIVERSITY OF WASHINGTON