Clinical Research in Human Fertility

这项申请提出了一个整合研究、教育和教学的五年计划，以培养在人口统计学、临床和人类生育能力的行为方面进行多学科研究的技能。这个奖项将会。在多学科和多视角的知名科学家的指导下，为申请者提供强化培训和指导。申请的具体目的是(1)加强候选人的研究培训，研究月经周期受孕概率标记物的临床应用，以实现正常生育能力和亚生育能力的怀孕；(2)获得与人类生育的临床和人口层面有关的人口学方法、流行病学方法和行为科学研究方法的深入培训；以及(3)获得关于人类生育的伦理问题的正式培训。培训计划包括(1)课程工作，(2)研究，(3)参加研讨会，(4)有针对性的教学经验。该研究计划收集数据以观察月经周期的最大临床可繁殖力-在已证实有生育能力的夫妇中，这是了解正常生育和不孕的重要信息。因此，研究计划旨在帮助应聘者发展成为一名独立的职业临床研究员所需的技能、方法和合作关系，与多学科研究团队合作研究人类生育能力。这项名为“生育意识对临床怀孕时间的影响”的研究计划是一项前瞻性随机试验，它将检验一种成熟的排卵方法(观察宫颈粘液的阴道排泄)对临床怀孕时间的影响，以及通过测量尿液中的黄体生成素来确定排卵前和排卵前6天内性交行为的分布。该项目将对寻求尽可能准确地确定受孕时间的正常生育能力的夫妇具有直接的临床意义。这也将有助于指导未来的研究，以更准确地描述不孕不育和不育。这些研究活动，以及人口统计学方法、流行病学方法、行为科学研究方法和伦理学的高级研究，将提供作为一名成功的、独立的临床研究员的终身职业所需的专业知识。斯坦福博士的长期目标是在人类生育能力的临床、人口统计学和行为方面的最终交汇点上开发一个研究计划。这一目标将通过在犹他大学继续担任教员并与多个学科的同事和学生合作来实现。犹他大学是一所主要的研究机构，拥有许多杰出的科学家，这为斯坦福博士提供了一个极好的环境来发展他的技能，并获得实现他的目标所需的专业知识。

This application proposes a five-year program integrating research, education, and teaching to develop skills for multidisciplinary research in demographic, clinical and behavioral aspects of human fertility. This award will. provide the applicant with intensive training and mentoring under the guidance of established scientists from multiple disciplines and perspectives. The specific aims of the application are (1) to enhance the candidate's research training to study the clinical application of markers of the probability of conception in the menstrual cycle to achieve pregnancy in normal fecundity and subfecundity; (2) to acquire in-depth training in demographic methods, epidemiologic methods, and behavioral science research methods as they relate to clinical and population dimensions of human fertility, and (3) to obtain formal training in ethical issues in human fertility. The training plan includes (1) course work, (2) research, (3) participation in seminars, (4) and targeted teaching experiences. The research plan collects data to observe the maximum clinically attainable fecundability of the menstrual cycle -in couples of proven fertility, information of importance for understanding normal fertility and infertility. Thus the research plan is designed to help the candidate to develop skills, methods, and collegial relationships needed to become an independent career clinical investigator working with multidisciplinary research teams to study human fertility. The research plan, "Effect of fertility awareness on time to clinical pregnancy," is a prospective randomized trial which will examine the effect of a proven method of identifying the approach of ovulation (the observation of vaginal discharge of mucus from the uterine cervix) on time to clinical pregnancy and distribution of acts of intercourse within a 6-day time period preceding and including ovulation, as determined by the measurement of LH in the urine. The project will be of immediate clinical relevance to couples of normal fertility seeking to time conception as precisely as possible. It will also help guide future research to more precisely describe subfecundity and infertility. The research activities, along with advanced studies of demographic methods, epidemiologic methods, behavioral science research methods, and ethics, will provide the expertise needed for a lifelong career as a successful, independent clinical investigator. Dr. Stanford's long-term goal is to develop a program of research at the end intersection of the clinical, demographic, and behavioral aspects of human fertility. This goal will be achieved by continuing and advancing in a faculty role at the University of Utah, working with colleagues and students in multiple disciplines. The University of Utah is a major research institution with many distinguished scientists which offers an excellent environment for Dr. Standford to develop his skills and gain the expertise needed to accomplish his goals.