SOUTHERN CALIFORNIA AIDS MALIGNANCY NETWORK

描述：(申请人描述) 艾滋病恶性病毒库成立于1994年，自1995年以来一直 由五个站点组成：加州大学旧金山分校、加州大学洛杉矶分校、乔治华盛顿大学、 纽约州立大学布鲁克林分校和俄亥俄州立大学。AMB是国家资源 这反映了样本中艾滋病毒疾病的恶性病史。 因为AMB的科学家们自己都在积极参与研究 艾滋病相关恶性肿瘤的发病机制，AMB对 艾滋病毒疾病的治疗和科学进展。目前，AMB 包含43个不同类别的12,688个个体标本。这些 体液、细胞和组织标本，以及相关的临床 世界各地的合格研究人员都可以获得这些信息。到目前为止，18 不同的调查人员在危急关头收到了900多个样本 通过独立研究和评估他们的意向书(LOIS) 该领域专家的评价决策小组(REDP)。 当前的重新竞争提案结合了所有AMB的信息 会员网站，以及报告成绩、未来计划、目标和 来自各个站点的预算预测。AMB的主要目标是：1) 建立一个运营中心，负责维护国家数据库， 协调AMB站点的活动，并与外部资源对接 如艾滋病相关恶性肿瘤协会和妇女的 机构间艾滋病毒研究和科学界；2)将AMB扩大到 作为大型肿瘤学临床和临床的标本库 流行病学财团，最终导致采购其 标本；3)通过以下方式提高能见度并扩大对AMB的使用 调查人员；以及4)进一步开发个人会员站点程序 增加标本采集量。 加州大学洛杉矶分校的AMB是最初出资的银行之一。到目前为止，它已经积累了 AMB中超过三分之一的病例(1503例中的579例)和三分之一 总体样本总数最高。银行已经分发了最大的 向18名经批准的调查人员中的5人收集标本。加州大学洛杉矶分校 AMB一直积极参与AMB指导委员会，并领导努力使 来自其他组织的样本，如艾滋病相关恶性肿瘤联盟 去了AMB。加州大学洛杉矶分校的AMB正在重新配置，以扩大其在 标本，增加对神经学和多部位尸检组织的接触， 并在主站点对额外存储的标本进行编目。在这 续签后，加州大学洛杉矶分校将从目前的三家医院扩大到10多家 年为90%以上的艾滋病毒感染者提供护理的医院 洛杉矶县。我们还将增加一个国际公认的艾滋病毒 神经病理学家。有了这些变化，我们预计将积累超过1,000 新增病例和5000多个新标本。加州大学洛杉矶分校的AMB也预计 通过AMC的领导将16,000多个标本从AMC带到AMB AMC临床试验002、007和009。在接下来的五年里，加州大学洛杉矶分校 AMB打算扩大其在AMB的领导地位。

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Bank was established in 1994, and since 1995 has been composed of five sites: UCSF, UCLA, George Washington University, SUNY-Brooklyn, and Ohio State University. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the p a t hogenesis of AIDS-related malignancies, the AMB is responsive to therapeutic and scientific advances in HIV disease. Currently, the AMB contains 12,688 individual specimens in 43 different categories. These fluid, cell, and tissue specimens, along with associated clinical information, are available to qualified researchers worldwide. To date, 18 different investigators have received over 900 specimens after critical evaluation of their Letters of Intent (LOIs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This current re-competition proposal combines information from all AMB member sites, as well as reporting accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish an Operations Center that will maintain the national database, coordinate activities of the AMB sites, and interface with external sources of specimens such as the AIDS-related Malignancy consortium and the Women's Interagency HIV Study, and the scientific community; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens; 3) to increase visibility and broaden the use to the AMB by investigators; and 4) to f u rther develop individual member site programs to increase specimen acquisition. The UCLA AMB was one of the original funded banks. To date, it has accrued over one third of all cases in the AMB (579 of 1503 cases) and the third highest total of specimens overall. The bank has distributed the largest collection of specimens to five of the 18 approved investigators. The UCLA AMB has been active in the AMB steering committee and led efforts to bring samples from other groups such as the AIDS associated malignancy consortium to the AMB. The UCLA AMB is being reconfigured to expand its reach for specimens, increase its access to neurologic and multi-site autopsy tissues, and catalogue additional stored specimens at the main site. In this renewal, UCLA will expand from its current three hospitals to over 10 hospital that provide care to over 90% of all patients with HIV infection in LA County. We will also add an internationally recognized HIV neuropathologist. With these changes, we anticipate accruing over 1,000 additional cases and over 5,000 new specimens. The UCLA AMB also expects to bring over 16,000 specimens from the AMC into the AMB through its leadership of AMC clinical trials 002, 007 and 009. Over the next five years, the UCLA AMB intends to expand its leadership position within the AMB.