ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT

产品说明：这是一个由罗切斯特大学牙科研究和生物化学教授劳伦斯·塔巴克博士指导的NRSA培训计划的更新申请。 该计划的主要目标是为追求学术牙科事业的个人提供细胞和分子生物学的研究培训。 这一目标将通过培训来实现：1）牙医谁是博士学位的候选人，2）牙医-发布日期：博士追求博士后水平的研究培训，3）学士学位持有人追求博士学位，和4）博士追求博士后研究培训在细胞和分子生物学领域。学员将根据他们的学术记录，以前的主管的建议，以及他们对口腔科学学术生涯的承诺进行选择。将作出特别努力，征聘和培训任职人数不足的少数族裔。申请博士学位的学生将通过大学的生物学和医学多学科课程入学，并由指导委员会决定。 入学后，将通过生物化学、生物学、生物物理学、牙科研究、微生物学和免疫学、神经生物学和解剖学、病理学、药理学、生理学和毒理学等部门为学员提供许多教学课程。 博士生必须参加核心课程和其他与其研究领域相关的额外课程。核心课程包括研究轮换，研究伦理，牙科研究研讨会，普通生物化学，发育生物学，细胞器的结构和功能，以及高级生物化学。经过三次实验室轮换（如有必要，四次轮换），学生将从参与教师中选择一名导师，他们积极开展1）基因调控，2）细胞信号转导，3）大分子结构和功能关系，或4）细胞发育生物学领域的研究。 博士候选人也将选择一个“家庭部门。" 此外，学院亦会成立论文指导委员会，以监察学生的研究进度。具有博士学位的学员也将被分配到参与实验室轮换后的教师之一。 对细胞和分子生物学教学课程的需求将根据个人情况确定。每年将接受三名博士后和三名博士前学员，以在整个项目期间稳定保持六至八名学员。

DESCRIPTION: This is a renewal application for a NRSA training program directed by Dr. Lawrence Tabak, Professor of Dental Research and Biochemistry at the University of Rochester. The main objective of this program is to provide research training in cellular and molecular biology to individuals pursuing careers in academic dentistry. This objective will be accomplished by training: 1) dentists who are candidates for the PhD degree, 2) dentist-Date Released: PhDs pursuing postdoctoral level research training, 3) baccalaureate degree- holders pursuing the PhD, and 4) PhDs pursuing postdoctoral research training in the field of cell and molecular biology. Trainees will be selected on the basis of their academic records, recommendations of previous supervisors, and their commitment to academic careers in oral science. Special efforts will be made to recruit and train underrepresented minorities. Admission for students seeking the PhD degree will be through the university multi-disciplinary Program in Biology and Medicine, and will be determined by a Steering Committee. After admission, many didactic courses will be offered to trainees through the Departments of Biochemistry, Biology, Biophysics, Dental Research, Microbiology and Immunology, Neurobiology and Anatomy, Pathology, Pharmacology, Physiology, and Toxicology. PhD candidates must take the core courses and other additional courses related to their research areas. The core courses include research rotations, ethics in research, dental research seminar, general biochemistry, developmental biology, structure and function of cellular organelles, and advanced biochemistry. After three laboratory rotations (if necessary, four rotations), students will choose a mentor from the participating faculty who are actively conducting research in the field of 1) gene regulation, 2) cellular signal transduction, 3) structure and function relationships of macromolecules, or 4) cellular developmental biology. The PhD candidates will also choose a "home department." A thesis guidance committee will be formed to monitor students' research progress. Trainees with a PhD degree will also be assigned to one of the participating faculty after engaging in laboratory rotations. The need for didactic courses in cell and molecular biology will be determined on an individual basis. Three postdoctoral and three predoctoral trainees will be accepted per year to steadily maintain six to eight trainees throughout the project period.