How material antibodies raised against receptors in the neonatal brain can give rise to antibody-mediated brain disporters

该项目的主要目的是了解纹状体形成的发育过程和分子原理，纹状体是一种受许多神经发育障碍影响的大脑结构，包括Tourette综合征和OCD，以及物质抗体在影响这种大脑结构正常发育中的作用。这一发现研究的结果将为大脑发育的哪些方面对物质抗体暴露敏感提供机制性见解，并为预防物质抗体介导的病理的新疗法提供理论基础。

The main aim of this project is to understand the developmental processes and molecular principles that underlie the formation of the striatum, a structure of the brain affected in many neurodevelopmental disorders including Tourette's syndrome and OCD, and the role of material antibodies in affecting the normal development of this brain structure. Outcomes of this discovery research will provide mechanistic insight into what aspects of brain development are sensitive to material antibody exposure and provide rationales for new therapies preventing material antibody-mediated pathologies.