ANESTHETICS AND CARDIOPROTECTIVE SIGNAL TRANSDUCTION

描述 （改编自申请人摘要）指导临床的候选人 科学家发展奖被授予医学博士学位的大学 威斯康星州，并完成了住院医师在麻醉学在大学 爱荷华州和威斯康星州医学院的研究奖学金。 期间 奖学金培训候选人研究了麻醉剂对 慢性内固定犬的冠状动脉血管反应性。 建议的奖励将使候选人能够完成以下工作 目标：1）发展广泛的科学知识基础 2）明确心肌保护的机制; 挥发性麻醉剂在缺血后再灌注心肌中的作用： （三）允许候选人独立规划和进行基础研究。 研究发展计划将促进候选人的成就 通过提供高等教育的机会， 分子和细胞生物学和心血管生理学， 不同的学术研究环境。 候选人将在她的指导 一个跨学科的心脏病学研究小组的努力， 生理学、药理学和麻醉学。 机会将 可供候选人介绍和讨论正在进行的研究， 其他年轻的研究人员在几个生产力，装备精良的实验室。 在这种环境下，候选人将调查 挥发性麻醉剂，异氟烷和氟烷，以调节心脏保护 信号转导 三磷酸腺苷调节钾的作用 （KATP）通道、腺苷受体和蛋白激酶C激活 吸入麻醉药促进顿抑心肌功能恢复的实验研究 并模拟缺血预处理将在 急性仪器狗。 将进行其他研究，以评价 这些麻醉剂对全细胞KATP电流的作用， 探讨缺血和麻醉药对G蛋白的相互作用 在心肌中的表达。 该奖项将为候选人的发展奠定基础， 一个独立的调查员，结果将最终有助于 改善心血管疾病患者的围手术期护理 疾病 (End摘要）

DESCRIPTION (Adapted from applicant's abstract) The candidate for the Mentored Clinical Scientist Development Award was awarded the MD degree from the University of Wisconsin and completed a residency in Anesthesiology at the University of Iowa and a research fellowship at the Medical College of Wisconsin. During fellowship training the candidate investigated the actions of anesthetics on coronary vascular reactivity in chronically-instrumented dogs. The proposed award will enable the candidate to accomplish the following objectives: 1) develop a broadly based foundation of scientific knowledge and research techniques; 2) define the mechanisms of cardioprotective actions of volatile anesthetics in post-ischemic, reperfused myocardium: and 3) allow the candidate to independently plan and conduct basic research. The research development plan will facilitate the candidate's accomplishment of these objectives by providing opportunities for advance education in molecular and cellular biology and cardiovascular physiology in a rich and varied academic research environment. The candidate will be directed in her efforts by an interdisciplinary group of investigators in cardiology, physiology, pharmacology and anesthesiology. Opportunities will be available for the candidate to present and discuss research in progress with other young investigators in several productive, well-equipped laboratories. Within this environment, the candidate will investigate the actions of the volatile anesthetics, isoflurane and halothane, to modulate cardioprotective signal transduction. The role of adenosine triphosphate-regulated potassium (KATP) channels, adenosine receptors and protein kinase C activation by volatile anesthetics to enhance functional recovery of stunned myocardium and to mimic ischemic preconditioning will be examined in acutely-instrumented dogs. Additional studies will be performed to evaluate the actions of these anesthetics on whole cell KATP currents and to investigate the interactions of ischemia and anesthetics on G protein expression in myocardium. This award will provide a foundation for the development of the candidate as an independent investigator, and the results will ultimately contribute to improvement in the perioperative care of patients with cardiovascular disease. (End of abstract)