DIET, ESTROGEN, AND INTERNATIONAL CANCER INCIDENCE

这个建议的目的是确定饮食，雌激素代谢和乳腺癌之间的联系。这将涉及与法国里昂国际癌症研究机构营养和癌症股的研究人员合作，进行欧洲癌症和营养前瞻性调查，这是一项对9个国家48万人进行的大型前瞻性研究。具体假设如下：1）特定雌激素代谢物血浆浓度升高的女性（16 α和4羟基代谢物）增加了乳腺癌和其他生殖道癌症的风险; 2）特定食物的消费与16 α和4羟基雌激素的血浆浓度降低以及生殖道癌症风险降低有关;和3）雌激素代谢物的血浆浓度与雌激素代谢相关酶的遗传多态性有关。这项研究可能会发现新的癌症风险生物标志物，可用于识别高风险女性，并制定预防癌症的饮食和生活方式策略。

The purpose of this proposal is to determine the associations among dietary, estrogen metabolism, and breast cancer. This will involve collaboration with researchers in the Nutrition and Cancer Unit of the International Agency for Research on Cancer in Lyon, France, on the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective study of 480,000 people in nine countries. The specific hypotheses are: 1) women with increased plasma concentrations of specific estrogen metabolites (16a and 4 hydroxy metabolites) are at increased risk of breast cancer and other cancers of the reproductive tract; 2) consumption of specific foods is associated with reduced plasma concentrations of 16alpha and 4 hydroxy estrogens, and lowered risk of cancers of the reproductive tract; and 3) plasma concentrations of estrogen metabolites are associated with genetic polymorphisms in enzymes associated with estrogen metabolism. This study may identify new cancer risk biomarkers that could be used to identify high risk women and to develop dietary and lifestyle strategies for cancer prevention.