PROSTATE NEOPLASM--CAREER DEVELOPMENT PROGRAM

前列腺癌研究领域的重大进展已经 近年来，相对于其他流行的癌症， 由于缺乏合格的、独立资助的调查人员， 这方面的主要兴趣。 建立SPORE中心， 前列腺癌研究的卓越成就已经解决了这个问题， 提供了一个重要的核心医生和科学家致力于 在互动和协作的环境中解决这个问题。 在癌症领域，SPORE中心面临的两个最大挑战 发展是1）聚集这一忠诚的调查人员核心 来自不同的临床和科学背景，并给予每个成员 与临床相关的核心基本背景信息 前列腺癌的行为和与有效治疗相关的问题 这种疾病的管理;和2）招募候选人异常高 前列腺癌的治疗方法有哪些 我们职业发展计划的总体目标是吸引 具有高度天赋和生产力的基础和临床科学家， 博士后水平，通过全国搜索，并把这些 实验室里的人采取令人兴奋和富有想象力的方法， 转化前列腺癌研究。 在过去的1.5年里， 战略为我们的机构带来了大量的年轻人才，我们 利用SPORE职业发展基金， 博士后研究员和8名新的初级教员主要感兴趣 前列腺癌的转化研究。 此外，令人兴奋的和 由我们的SPORE产生的协作知识环境吸引了 至少5个不同部门的18名既定调查员， 他们的大部分研究工作都是在转化前列腺， 癌症研究。 虽然SPORE资金的可用性， 发展研究项目和部分薪金支助是有益的 吸引年轻和成熟的研究人员研究前列腺癌 研究，我们在这方面的整体努力已大大超过了直接 由SPORE提供支持。 我们成功地使用了SPORE资金， 研究员和初级教师的种子招聘，我们利用这些 资金，以确保从贝勒医学院的额外支持， 学院的各个部门和私人基金会。 的 过去2.5年用于雇用和支助的资金总额 转化性前列腺癌领域的初级教员和研究员 研究表明，超过80%的人来自SPORE职业生涯之外 发展计划。 我们估计前列腺孢子的存在 在贝勒医学院已经产生了额外的100万美元， 机构和私人基金会对培训的支助 奖学金 在未来五年，我们建议善用 我们的多学科，多部门，多人才的SPORE 研究人员，以吸引更多的研究员，初级教师， 已建立前列腺癌转化研究的研究人员。 的 充满活力的环境围绕我们的SPORE会议，研讨会， 研究项目应能大大促进这些努力。

Significant advances in the field of prostate caner research have been limited in recent years relative to that of other prevalent cancers mainly because of a dearth of qualified, independently-funded investigators with primary interests in this area. The establishment of SPORE centers of excellence in prostate cancer research have addressed this problem by providing a significant core of physicians and scientists committed to addressing this problem in an interactive and collaborative environment. The two greatest challenges to SPORE centers in the area of cancer development have been 1) to assemble this committed core of investigators from diverse clinical and scientific backgrounds, and to give each member of this core essential background information related to the clinical behavior of prostate cancers and the problems associated with effective management of this disease; and 2) to recruit candidates of unusually high merit to the field of prostate cancer research. The overall goal of our career development program has been to attract highly talented and productive basic and clinical scientists at the postdoctoral level through a national search, and to place these individuals in laboratories taking exciting and imaginative approaches to translational prostate cancer research. During the past 1.5 years, this strategy has brought a wealth of young talent to our institution, and we have used the SPORE Career Development Funds to help attract 45 postdoctoral fellows and 8 new junior faculty members primarily interested in translational prostate cancer research. In addition, the exciting and collaborative intellectual environment generated by our SPORE has attracted 18 established investigators in at least 5 different departments to devote a substantial portion of their research efforts to translational prostate cancer research. Although the availability of SPORE funds for developmental research projects and partial salary support have been useful in attracting both young and established investigators to prostate cancer research, our overall effort in this area has vastly exceeded the direct support provided by the SPORE. We have successfully used SPORE funds to seed recruitment of fellows and junior faculty, and we have leveraged these funds to secure additional support form Baylor College of Medicine, individual departments at the College, and private foundations. Of the total funds expended during the past 2.5 years for hiring and supporting junior faculty and fellows in the area of translational prostate cancer research , more than 80% have come from outside of the SPORE Career Development Program. We estimate that the presence of the prostate SPORE at Baylor College of Medicine has generated an additional 1,000,000.00 per year in Institutional and private foundation support for training fellowships. Over the next five years, we propose to use the strengths of our multi-disciplinary, multi-departmental, and multi-talented SPORE investigators to attract additional fellows, junior faculty, and established investigators to translational prostate cancer research. The vibrant environment surrounding our SPORE conferences, seminars, and research projects should greatly facilitate these efforts.