CORE--HUMAN TISSUE RESOURCE AND LOGISTICS

该SPORE中的所有项目都使用人类标本进行转化研究 旨在降低结肠直肠癌的发病率和死亡率， 胰腺癌 建立了人体组织资源与物流中心 在1986年为肠道建立的非常成功的现有银行的基础上， 肿瘤工作组。 截至1995年底，资源包括910 结直肠癌切除术169例，结直肠腺瘤切除术52例， 结直肠息肉切除标本，62例肝切除转移 结直肠癌，20例胰腺癌切除术，112例异种移植物 结直肠癌，97例胰腺癌移植瘤，127例粪便移植瘤， 2574份血液标本。 收集机制 SPORE的研究活动所需的标本仍然存在 在不同的病人接触位置。 这一核心设施银行广泛 结直肠和胰腺切除标本的组织范围 癌的 该资源提供粪便和血液的采购 包括外周血白细胞、血浆和血清，以及 作为ERCP液体、鼻胃和十二指肠囊液以及腹膜 洗涤物。 核心支持结肠直肠和胰腺的异种移植 裸鼠的癌症。此外，还介绍了一种 饮食史和家族标准化食物频率问卷 通过核心对样本在 Resource.核心包括一个数据库管理机制， 样本分发，包括确定所需样本优先次序的程序 约翰霍普金斯GI癌症孢子内外的材料。 现行程序可为研究样本提供质量控制 而不损害诊断、临床重要病理 通过病理学家的参与对标本进行评价， 结肠直肠癌和胰腺癌的专业知识。 临床成员 与患者有主要接触的部门是个人的参与者， 研究项目，从而也有助于核心的最大和 有效积累满意标本。

All programs in this SPORE use human specimens for translational research directed at reducing the incidence of and mortality from colorectal and pancreatic cancer. The Human Tissue Resource and Logistics Core was built upon the highly successful existing bank established in 1986 for the Bowel Tumor Working Group. At the end of 1995, the Resource included 910 colorectal cancer resections, 169 colorectal adenoma resections, 52 colorectal polypectomy specimens, 62 hepatic resections for metastatic colorectal cancer, 20l pancreatic cancer resections, 112 xenografts of colorectal carcinoma, 97 xenografts o pancreatic carcinoma, 127 fecal specimens, and 2574 blood specimens. The mechanisms for collecting specimens required for the research activities of the SPORE remain in place in the various patient contact locations. This Core facility banks a wide range of tissues from resection specimens for colorectal and pancreatic cancers. The Resource provides for procurement of fecal and blood specimens, including peripheral blood leukocytes, plasma and serum, as well as ERCP fluids, nasogastric and duodenal capsule fluid, and peritoneal washings. The Core supports xenografts of colorectal and pancreatic cancers in nude mice. In addition, the distribution and retrieval of a standardized food frequency questionnaire for dietary history and family history is carried out through the Core for patients with specimens in the Resource. The Core includes a mechanism for database management and specimen distribution, including procedures for prioritization of requested materials within and external to the Johns Hopkins GI Cancer SPORE. The existing procedures provide quality control of specimens for research without compromise of the diagnostic, clinically important pathological evaluation of the specimens via the participation of pathologists with expertise in colorectal and pancreatic cancer. Members of the clinical departments with primary patient contact are participants in the individual research projects and thus also contribute to the Core for maximal and effective accumulation of satisfactory specimens.