Defining the risk of wildlife-associated bunyaviridae infections to UK livestock

轮岗将使学生接触到与新兴病毒检测领域相关的技术。具体来说，他们将学习如何编译和操作病毒序列数据集，进行相关的生物信息学分析，以定义遗传相关性，并促进适当的退化PCR引物设计。然后，学生将有机会将这些引物组应用于野生啮齿动物组织样本，使用人类样本集作为对照，以确定布尼亚病毒在这一重要野生动物库中的流行程度。如果时间允许，学生还将获得病毒培养技术和替代感染性测定的实践经验。

The rotation will expose the student to techniques relevant to the field of emerging virus detection. Specifically they will learn how to compile and manipulate virus sequence datasets, perform relevant bioinformatics analyses to define genetic relatedness and facilitate with appropriate degenerate PCR primer design. The student will then have the opportuity to apply these primer sets to wild rodent tissue samples, using a human sample set as control, to define the prevalence of bunyaviruses in this important wildlife reservoir. If time permits, the studnet will also gain hands-on experience of the virus culture techniques and surrogate infectivity assays.