CORE--BIOSTATISTICS

生物统计学核心将：1）提供研究设计和统计和遗传分析方面的建议，包括样本量和功效计算。2)对人口和家庭数据进行统计分析，包括数据转换和调整。3)对群体和家系数据进行遗传分析，包括：a）数量性状和质量疾病状态与遗传标记的两点和多点连锁分析，以及B）疾病状态和数量性状与遗传标记的关联的基于家系和群体的测试。4)帮助解释分析结果，以确定研究计划的下一步。5)提供实验设计和计算机分析鼠杂交数据的建议。6)在基因组数据库的使用中提供生物信息学支持，以帮助构建EST重叠群和识别数据库中长距离序列的编码区。

The Biostatistics Core will: 1) Provide advice on research design and statistical and genetic analyses, including sample size and power calculations. 2) Conduct statistical analyses of population and family data, including data transformations and adjustments. 3) Conduct genetic analyses of population and family data, including: a) two-point and multi-point linkage analyses of quantitative traits and qualitative disease status with genetic markers, and b) family and population based tests of association of disease status and quantitative traits with genetic markers. 4) Aid in the interpretation of the results of analyses to identify the next steps in a research plan. 5) Provide advice on experimental design and computer analyses of data generated by murine crosses. 6) Provide Bioinformatics support in the use of genome databases to aid in the construction of EST contigs and the identification of the coding regions on long rage sequences in databases.