COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

描述：(改编自申请者摘要)本研究的总体目标 是提供四个过程和结果的全面图景 特殊人格障碍(PD)：分裂型(STPD)、边缘型(BPI)、 回避型(AvPD)和强迫症(OCPD)。目前的建议 继续多站点协作努力，跟踪经过仔细诊断的 具有代表性PD或专业的668名受试者的样本 抑郁障碍(MDD)(对照)，从2岁到至少6岁 在招募数年后。采用前瞻性的、纵向的、重复的措施 设计，我们将开发相同的关于过程和结果的基本知识 先前由类似的情感性研究引起的PD 和焦虑症，从而解决了我们知识中的一个重要差距。这个 延长的随访期对于辨别临床有意义是必不可少的 对过程和结果的描述及其决定因素。样本量很大 在人口统计上足够和足够多样化，以获得独特的 结果推广到大多数临床环境。 为了实现我们的总体目标，我们提出了三种方法。 可预测性，以及三、验证性。描述性方法将提供以下数据 动脉导管未闭的诊断稳定性，对I轴的存在和进程的影响 关于功能障碍的持续性，以及关于对 卫生保健资源，允许比较PD和类似的数据 I轴紊乱。预测性方法将确定有临床意义的 PD内和跨PD预后的决定因素。验证方法将 检查PD的描述性和纵向特征的同质性， 如DSM系统所定义的，以及这与替代方案如何比较。

Description: (Adapted from Applicant's Abstract) The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPI), avoidant (AVPD), and obsessive-compulsive (OCPD). The present proposal continues a multi-site collaborative effort to follow a carefully diagnosed sample of 668 subjects having either these representative PDs or major depressive disorder (MDD) (controls) for the period from 2 to a minimum of 6 years after recruitment. Using a prospective, longitudinal, repeated measures design, we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders, thus addressing an important gap in our knowledge. The extended period of follow-up is essential to discern clinically meaningful descriptions of course and outcome and their determinants. The sample is large enough and sufficiently diverse demographically to attain a unique array of results generalized to most clinical settings. To accomplish our overall aim, we propose three approaches I. Descriptive, II. Predictive, and III. Validating. The descriptive approach will provide data on diagnostic stability of PDs, on presence and course of comorbid Axis I disorders, on persistence of functional impairment, and on utilization of health care resources that allow comparison between the PDs and similar data on Axis I disorders. The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs, as defined by the DSM system, and how this compares with alternative schemes.