FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS

描述(申请人摘要)：丰富的数据，包括最近的 连锁研究表明，顺畅追逐眼球运动的异常 标出精神分裂症的表型。缺乏警觉性、工作记忆力和 其他神经认知功能经常被观察到的亲属 精神分裂症患者，并被认为是推定的表型标记。 尽管有这些丰富的数据，但有几个问题仍然不清楚。什么是 寻踪异常的精确神经生理机制 精神分裂症谱系？各种推定的责任标记是否相互关联？ 是不是一些认知测量标志着 表型(或另一种表型)？考虑到这些问题， 应用广泛的目的是：i)应用改进的方法来评估流畅性 追踪眼球运动功能对脑梗塞患者亲属的研究 为了了解精神分裂症的神经生物学遗传学 精神分裂症的易感性；ii)证明改进的措施 顺利追踪确定有风险的亲属(即，有 精神分裂症谱系人格特征，如建议的高准确率 根据我们的初步数据；以及iii)确定 各种表型标记及其是否有独立贡献 在鉴定一种表型时。 我们计划招收四个科目：(1)生物学士学位 无SSP症状的精神分裂症患者亲属(n=30)和(2) (n=30)；(3)无精神病家族史的社区受试者 伴SSP症状30例，无SSP症状4例。我们将管理一个 一组眼球运动和神经认知测试 研究对象。关于平滑的本质，我们有一个特定的假设 在分裂类型中追求异常。这一假设将使用以下方法进行评估 眼球运动和其他认知(例如，工作记忆)任务。其他 将对这四组人的神经认知指标进行比较。我们会的 单独探索眼球跟踪测量、认知测量的能力 以及在准确预测相对状态方面的措施组合。

DESCRIPTION (Applicant's abstract): A wealth of data, including a recent linkage study, suggest that abnormalities in smooth pursuit eye movements mark the schizophrenia phenotype. Deficits in vigilance, working memory and other neurocognitive functions are frequently observed in relatives of patients with schizophrenia and are considered putative phenotypic markers. In spite of these rich data, several issues remain unclear. What is the precise neurophysiologic mechanism underlying the pursuit abnormality in schizophrenia spectrum? Are various putative liability markers correlated? Are some of the cognitive measures marking a different dimension of the phenotype (or a different phenotype)? With these questions in mind, the application broadly aims to: i) apply refined methods of evaluating smooth pursuit eye movement function to studies in relatives of patients with schizophrenia in order to understand the neurobiology of genetic vulnerability to schizophrenia; ii) to demonstrate that the refined measures of smooth pursuit identify relatives at risk (i.e., relatives with schizophrenia spectrum personalities, SSP) with high accuracy as suggested by our preliminary data; and iii) to determine the relationship among various phenotypic markers and whether they make independent contributions in identifying a phenotype. We plan to recruit four groups of subjects (1) first degree biological relatives of schizophrenic patients with (n=30) and (2) without SSP symptoms (n=30), and (3) community subjects with no known family history of psychosis with (n=30) and (4) without SSP symptoms (n=6O). We will administer a battery of eye movement and neurocognitive tests in these groups of subjects. We have a specific hypothesis regarding the nature of smooth pursuit abnormality in schizotypy. This hypothesis will be assessed using ocular motor and other cognitive (e.g., working memory) tasks. Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status.