Early life arsenic exposure alters lung development and inflammatory responses to virus and cigarette smoke

饮用水源受砷污染是一个影响数百万人的全球性健康问题。虽然砷是一种众所周知的致癌物，但最近的证据表明，早年通过饮用水接触砷会增加晚年患阻塞性肺病的风险。该项目旨在研究砷暴露的时间和剂量如何影响肺部发育和对呼吸道损害（包括病毒感染和香烟烟雾）的反应。

The contamination of drinking water sources with arsenic is a global health issue affecting millions. While arsenic is a well known cancer causing agent, recent evidence suggests that early life arsenic exposure via drinking water increases the risk of obstructive lung disease in later life. This project aims to examine how the timing and dose of arsenic exposure influences lung development and the response to respiratory insults including viral infection and cigarette smoke.