EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY

描述：(申请人描述)在此续期申请中，我们寻求 支持几个创新教育项目的开发和评估 肿瘤学思维帽(OncoTCap)的应用，一个计算机系统， 提供广泛且高度灵活的癌症建模实验室，使 一系列教育干预措施。OncoTCap的核心是一对 模拟异质肿瘤进化的计算引擎， 基于对生物学假设的经济描述。人口可以 观察癌症治疗的演变和反应，OncoTCap还包括 一套支持教育工作者使用该系统的接口程序， 实习生和研究人员。这些接口可用于升级 对癌症治疗的重要问题的认识和支持 假设生成。 在我们最初的赠款下完成的工作的基础上，我们准备 OncoTCap能力的极大扩展，涉及以下方面 建模能力和新的或改进的界面。反过来，扩张将会， 使我们能够开发和评估新的和强化的癌症干预措施 加强基础科学研究、临床研究和患者的教育 关心。与癌症相关的新教育干预计划 教育工作者包括： 1.专家界面和癌症信息精灵在三个领域的应用 癌症联谊会计划，以加速渗透、整合和 癌症生物学新知识在研究和临床实践中的实用性； 2.临床试验向导在高等医学院的应用 癌症选择性地传达四个主要药物阶段的经验 发展； 3.患者接触界面在持续培训中的应用 肿瘤学住院医师计划，重点是患者管理技能。

DESCRIPTION: (Applicant's Description) In this renewal application, we seek support for development and evaluation of several novel educational applications of the Oncology Thinking Cap (OncoTCap), a computer system that provides an extensive and highly flexible cancer modeling laboratory enabling a range of educational interventions. The heart of OncoTCap is a pair of computational engines that simulate the evolution of heterogeneous tumors, based on an economical description of biological assumptions. Populations can be observed to evolve and respond to cancer treatments, OncoTCap also includes a set of interface programs that support the system's use by educators, trainees, and researchers. These interfaces can be used to promote understanding of important issues of cancer treatment and to support hypothesis generation. Building on the work performed under our initial grant, we are poised to make highly significant expansions in OncoTCap's capabilities, in regard to modeling power and new or improved interfaces. The expansions will, in turn, allow us to develop and evaluate new and augmented interventions in cancer education to enhance basic science research, clinical research, and patient care. The new educational interventions planned in conjunction with cancer educators include: 1. Utilization of Expert Interface and Cancer Information Genie in three cancer fellowship programs to accelerate the penetration, integration and usability of new cancer biology knowledge in research and clinical practice; 2. Utilization of the Clinical Trial Wizard in a medical school advanced cancer selective to convey experience with four major stages of drug development; 3. Utilization of the Patient Encounter Interface in an ongoing training program for oncology residents, focused on patient management skills.