FASEB Conference--Muscle Satellite & Stem Cells

该申请要求部分资助2001年FASEB肌肉卫星和干细胞夏季会议。会议将于2001年7月14日至19日在亚利桑那州图森市的Omni Tucson National Resort & Spa举行。这次跨学科会议将集中在我们对肌肉卫星细胞和干细胞的理解的最新进展。肌肉卫星细胞是肌肉正常生长、修复受损或患病肌肉以及在衰老期间维持力量所需的肌源性细胞。肌源性干细胞是最近发现的一小群多能细胞，可以产生卫星细胞，并有助于血液和骨组织的形成。本次会议的目的是提供一个单一的论坛，其中正在进行骨骼肌卫星和干细胞功能研究的不同科学家群体可以讨论他们的最新工作并确定未来的方向。这次会议是专门为那些通常不参加同一次会议的科学家们而设计的，并为新的研究人员和想法提供了一个乐于接受的听众。会议将重点讨论肌肉干细胞的起源和命运，正常肌肉生长，损伤后和疾病期间的肌肉再生，肌肉可塑性和适应机制，细胞凋亡和坏死的肌肉特异性机制，以及肌肉衰老的机制和干预措施。这些领域的进展非常迅速，因为研究集中在卫星和干细胞调节和功能的分子机制上。由于这一领域的重要进展速度很快，会议应提供一个及时和重要的论坛，以讨论新的工作和制定新的实验方法。

This application requests funding to partially support the 2001 FASEB Summer Conference on Muscle Satellite and Stem Cells. The conference will take place July 14-19, 2001 at the Omni Tucson National Resort & Spa in Tucson, Arizona. This interdisciplinary conference will focus on recent advances in our understanding of muscle satellite cells and stem cells. Muscle satellite cells are the myogenic cells that are required for normal muscle growth, repair of injured or diseased muscle, and maintenance of strength during aging. Muscle-derived stem cells are a recently identified small population of multipotent cells that can produce satellite cells, as well as contribute to the formation of blood and bone tissue. The purpose of this conference is to provide a single forum in which the diverse group of scientists who are conducting research on the functions of skeletal muscle satellite and stem cells can discuss their newest work and set future directions. The conference is designed specifically to bring together scientists who usually don't attend the same meetings and to provide a receptive audience for new investigators and ideas. Conference sessions will focus on muscle stem cell origins and fates, normal muscle growth, muscle regeneration after injury and during disease, mechanisms of muscle plasticity and adaptation, muscle-specific mechanisms of apoptosis and necrosis, and mechanisms and interventions in muscle aging. Progress in these fields has become very rapid as research has focused on the molecular mechanisms underlying satellite and stem cell regulation and function. Due to the rapid pace of important advancements in this field, the conference should provide a timely and important forum to discuss new work and to develop new experimental approaches.