DNA MICROARRAYER AND SCANNER SYSTEM

共享DNA微阵列的建立将使该机构的研究人员能够利用基因组研究的重大进展。参与该应用的研究者包括参与研究人类、小鼠、大鼠、酵母和大肠杆菌基因的用户。杆菌仪器、专用设备和材料，加上机构和部门资金形式的内部支持，以及研究人员协调和监督该设施的承诺，将使我们能够建立一个最先进的DNA微阵列设施，为罗伯特·伍德约翰逊医学院和罗格斯大学的研究人员提供服务。目前，这些相邻校园的研究人员没有能力利用这种先进的技术。DNA微阵列系统将使研究人员能够更容易地发现参与控制各种生物体中大量途径和反应的基因。购买这种仪器将提高与癌症、信号传导、分化和发育、耐药性和许多其他途径研究有关的基因发现率。这些研究人员对DNA微阵列系统的需求在现有条件下无法满足。新泽西没有一个学术机构拥有合适的仪器和设备来准备和开展DNA微阵列的工作。此外，由于研究人员对DNA微量分析的巨大需求，与其他机构的合作极为有限。此外，任何这种潜在的合作都将受到长途旅行的阻碍。此外，没有一个用户能够负担得起目前的仪器来建立DNA微阵列。所要求的仪器将为这个校园的研究人员提供一个重要的新机会，这是他们在这些大学的任何地方都无法获得的。这是为数不多的仪器支持赠款之一，将使整个研究环境发生重大变化，并将提供一个独特的机会，使基础科学和临床应用的重大进展。

The established of a shared DNA microarray would allow investigators at this institution to take advantage of the major advances made in genome research. Investigators that are participating in this application comprise users that are involved in studying genes from humans, mice, rats, yeast and E. coli. The instrumentation, specialized equipment and materials, together with internal support in the form of institutional and departmental funds, as well as the commitment from investigators to coordinate and supervise this facility will enable use to establish a state of the art DNA microarray facility that will serve the investigators from Robert Wood Johnson Medical School and Rutgers University. Currently the investigators on these contiguous campuses do not have the ability to utilize this advanced technology. The DNA microarray system will permit investigators to make major inroads in more readily discovering the genes involved in controlling a wide number of pathways and responses in various organisms. The rate of gene discovery related to investigations in cancer, signal transduction, differentiation and development, drug resistance and many other avenues will be enhanced by the purchase of this instrumentation. The need of these researchers for a DNA microarray system cannot be met under existing conditions. There is no academic institution in New Jersey that has the appropriate instrumentation and a facility to prepare and carry out work with DNA microarrays. Furthermore, collaborations with other institutions have been extremely limited because of the enormous demand by investigators for DNA micro analysis. In addition, any such potential collaborations would be hampered by the long distance. Moreover, no one user could afford the current instrumentation to establish a DNA microarray. The instrumentation requested will provide a major new opportunity to investigators on this campus that is not available to them any place at these universities. This is one of the few instrumentation support grants that will make a major change in the entire research environment and will provide a unique opportunity to make major inroads in basic sciences and clinical application.