CCD DETECTOR TO UPGRADE AN X-RAY DIFFRACTOMETER

需要资金将现有的单晶P4 X射线衍射仪升级为新一代电荷耦合器件探测器。该仪器将通过促进对抗病毒药物开发、放射性药物开发、通过有机金属试剂进行药物合成、环境友好的催化和加工以及晶体工程等项目的关键分子或材料的表征，直接和立即影响NIH资助的几个项目。只有通过这种仪器才能获得具有强大抗病毒活性的大型复杂簇合物(多金属氧酸盐)(艾滋病毒、乙肝、呼吸道合胞病毒和流感)和“绿色”加工的关键结构信息。最近引入结晶学的新技术，通过将ccd探测器耦合到调谐到钼和铜辐射的荧光粉，提供的数据质量远远优于我们目前使用的1970年代的S技术。它将使我们能够通过可靠的密封管源获得更高质量的数据。在埃默里大学化学系和放射学系进行的大部分合成化学研究中，钼辐射对于分析高吸收金属团簇和化合物是必不可少的。CCD探测器将使数据收集更快，使我们能够将结晶学作为合成化学家的常规但高精度的结构工具。利用内部资源聘请了一名专业结晶师来管理设施，并为不同的合成无机、有机金属、有机和药物化学家提供结构数据。总之，所要求的升级不仅将极大地提高埃默里大学化学系和医学院的不同研究人员的生产力，而且还将提高他们的科学素质。

Funds are requested to upgrade an existing single crystal P4 X-ray diffractometer with a new generation CCD detector. This instrument will directly and immediately impact several NIH funded programs by facilitating characterization of key molecules or materials central to programs in antiviral agent development, radiopharmaceutical agent development, pharmaceutical synthesis via organometallic reagents, environmentally benign catalysis and processing, and crystal engineering. Critical structural information on large complex cluster compounds (polyoxometalates) with potent antivira1 activity (HIV, hepatitis B, respiratory syncytial virus, and influenza) and "green" processing can only be acquired through such instrumentation. The new technology recently introduced to crystallography by the coupling of a CCD detector to phosphors tuned to molybdenum and copper radiation affords data of quality far superior to the 1970's technology that we currently use. It will allow us to obtain better quality data with a reliable sealed tube source. Molybdenum radiation is essential for analysis of highly absorbing metal clusters and compounds that are prevalent in much of the synthetic chemical research conducted in the Chemistry Department and Department of Radiology at Emory University. The CCD detector will make data collection more rapid, allowing us to trot crystallography as a routine, but highly accurate, structural tool for synthetic chemists. A Staff Crystallographer has been hired using internal resources to manage the facility and provide structural data for a diverse group of synthetic inorganic, organometallic, organic, and pharmaceutical chemists. In summary- the requested upgrade will greatly enhance not only the productivity but also the quality of science of a diverse group of researchers in the Chemistry Department and School of Medicine at Emory University.