HCMV GB TRAFFICKING IN POLARIZED EPITHELIAL CACO 2 CELLS

骨髓移植是治疗白血病的有效方法。然而，医源性免疫抑制使患者易因人巨细胞病毒（HCMV）感染而患病。在体内，成纤维细胞、神经元细胞和上皮细胞被HCMV感染。在这些细胞类型中，了解必需病毒蛋白复合物gB运输到感染性病毒生产位点的机制可能对产生新的抗病毒化合物很重要。本提案的目的是研究gB在上皮细胞系（Caco-2）中的运输机制。

Bone marrow transplantation is an effective treatment for leukemia. However, the iatrogenic immunosuppression leaves the patient susceptible to disease as a result of human cytomegalovirus (HCMV) infection. In vivo, fibroblastic, neuronal and epithelial cells are infected by HCMV. In these cell types, understanding the mechanisms by which the essential viral protein complex gB traffics to the site(s) of infectious virus production may be important for the generation of new anti-viral compounds. The aim of this proposal is to investigate the trafficking of mechanisms of gB in an epithelial line (Caco-2).