Non-invasive System for and Arrest of Periodontitis

描述：此应用程序的目标是为 牙周病的早期防治。这将是 通过开发一种粘性的、可生物降解的水凝胶来实现 混合后离子凝胶在牙周袋内的形成 液体成分。这种凝胶会附着在现有的细菌菌斑上，并抑制 细菌的生长、黏附和渗透。该应用程序建议 胶原、肝素三种不同聚阴离子壳聚糖水凝胶的研制 还有聚乳酸。与物理性能相关的最佳凝胶组成 口服相关条件下的稳定性、胶凝时间、生物降解性、氧气 对口腔表面的渗透性和附着性将进行测定。的能力 最适合抑制口腔细菌生长和黏附的凝胶 将会被评估。 建议的商业应用： 开发一种预防和治疗早期牙周炎的非侵入性系统将允许创造一种家用产品。使用本产品可避免晚期牙周病。该产品将成为昂贵的牙周手术治疗的负担得起的替代品，并将为世界人口带来更好的牙齿健康。

DESCRIPTION: The goal of this application is to create a system for the prevention and treatment of the early stages of periodontal disease. This will be accomplished by developing an adhesive, biodegradable hydrogel that will form inside the periodontal pocket following ionotropic gelation of mixed liquid components. The gel will adhere to existing bacterial plaque and inhibit the growth, adherence and penetration of bacteria. The application proposes to develop a chitosan hydrogel with three different polyanions: collagen, heparin and polylactic acid. The optimal gel composition with regard to physical stability in orally relevant conditions, gelation time, biodegradation, oxygen permeability and attachment to oral surfaces will be determined. The ability of the most appropriate gel to inhibit the growth and adhesion of oral bacterial will be assessed. PROPOSED COMMERCIAL APPLICATION: Development of a non-invasive system for prevention and treatment of early periodontitis will allow to create a product for home application. The use of this product will result in avoiding advanced periodontal disease. The product will become an affordable alternative to expensive periodontal surgical treatment and will result in better dental health of the world population.