Efficacy of Thin HA Coating Produced by a Novel Process

第一阶段申请的目的是评估 离子束辅助沉积（IBAD）工艺用于涂覆的适用性 钛牙科植入物与薄羟基磷灰石（HA）层。涂层 将在狗中产生、表征和测试不同的结晶度 模型将根据骨-植入物界面评价植入物性能 和界面强度。本研究获得的数据将证明 IBAD工艺用于涂层牙科植入物的可行性，并有助于 开发适当的涂层结晶度，以获得最佳骨质量 反应使用薄涂层的基本原理是，尽管HA 有报道称，较薄的HA涂层有利于初始骨整合， 以具有比较厚涂层更大的界面结合强度。此外，本发明还提供了一种方法， 因为骨整合是由涂层的溶解刺激的 植入早期，植入物失效，由于内部分层 没有观察到HA涂层。 拟定商业应用： 低温薄膜沉积工艺将用于涂覆薄的羟基磷灰石（HA）膜，以优化骨对牙科植入物的反应。其他潜在的商业应用还包括在骨科植入物上应用涂层。这项技术将是成本中性的。此外，牙科和骨科HA涂层种植体在涂层种植体界面强度、更好地控制材料性能、后期不存在涂层分层以及优化早期骨整合方面上级当前的等离子喷涂工艺。

The purpose of this Phase 1 application is to evaluate the applicability of an ion beam-assisted deposition (IBAD) process for coating titanium Dental implants with a thin hydroxyapatite (HA) layer. Coatings of different crystallinity will be produced, characterized and tested in a dog model. Implant performance will be evaluated in terms of bone-implant interface and interfacial strength. Data obtained from this study will demonstrate the feasibility of the IBAD process for coating Dental implants and contribute to the development of an appropriate coating crystallinity for optimum bone response. The rationale for using thin coatings is that although HA is beneficial for initial osseointegration, thinner HA coatings have been reported to have greater interfacial bond strengths than thicker coatings. In addition, because osseointegration is stimulated by the dissolution of the coating during the early implant period, implant failure, as a result of delamination within the HA coating is not observed. PROPOSED COMMERCIAL APPLICATION: The low temperature thin film deposition process will be used to coat thin hydroxyapatite (HA) films for optimizing bone response to dental implants. Other Potential commercial applications will also include the application of coatings on orthopaedic implants. This technology will be cost neutral. In addition, dental and orthopaedic HA coated implants will be superior to the current plasma spraying process in terms of coating implant interfacial strenght, better control of the materials properties, absence of coating delamination at a later stage, and optimization of early osseointegration.