Wavelet-Based AROS Compresion of Cytogenetic Images

描述（由申请人提供）：本项目的目标是开发 创新的图像压缩技术，使数字存储，存档， 细胞遗传学图像的传播更加高效、快捷， 从而显著降低数字存储和传输成本， 临床诊断和遗传学中的细胞遗传学成像仪器， 癌症研究。我们的方法利用了大多数细胞遗传学 图像，细胞遗传学家感兴趣的区域被很好地确定， 在存储之前进行分割。最近发展起来的基于小波的任意区域 支持度（AROS）编码方法提供了一种有效的手段， 图像压缩，并承诺显着改善目前 可用的技术。 在第一阶段，我们将研究基于小波的AROS压缩的可行性， 单色细胞遗传学图像。我们将从压缩的角度进行评估 测试图像的压缩比、压缩增益、编码速度和容错能力 包括0-显带的染色体展布和核型、FISH和cDNA图像。如果 所提出的方法可以实现显著的改进，在第二阶段， 技术将扩展到多光谱FISH/M-FISH和cDNA，并进行测试 微阵列图像。当这项新技术完全开发出来后， 可供Applied Imaging（AIC）集成到PowerGene中 细胞遗传学自动化产品。这将带来更高的成本效益 商业工具。 拟定商业应用： 一旦新技术被开发出来并能用于常规应用， 将提供给AIC，以纳入PowerGene产品线， 细胞遗传学自动化设备，无论是在新的系统出售，并作为升级， 细胞遗传学实验室已经使用的现有系统，从而使该技术商业化 快

DESCRIPTION (provided by applicant): The goal of this project is to develop innovative image compression techniques to make the digital storage, archiving, and communication of cytogenetics images much more efficient and faster, thereby significantly reducing the storage and transfer costs of digital cytogenetics imaging instruments in clinical diagnosis and in genetics and cancer research. Our approach takes advantage that, for mostcytogenetics images, the regions of interest to cytogeneticists are well determined and segmented before storage. The recently developed wavelet-based arbitrary region of support (AROS) coding approach offers an effective means of region-segmented image compression, and promises significant improvement over currently available techniques. In Phase 1 we will study the feasibility of wavelet-based AROS compression of monochrome cytogenetics images. We will evaluate in terms of compression ratios, compression gains, coding speed, and error resilience on test images including 0-banding chromosome spreads and karyotypes, FISH and cDNA images. If the proposed approach can effect a significant improvement, in Phase 2 the technique will be extended to and tested on multispectral FISH/M-FISH and cDNA microarray images. When fully developed, the new technology will be made available to Applied Imaging (AIC) for integration into the PowerGene cytogenetics automation products. This will result in far more cost-effective commercial instruments. PROPOSED COMMERCIAL APPLICATION: As soon as the new techniques are developed and qualified for routine application, they will be made available to AIC for incorporation into the PowerGene product line of cytogenetics automation equipment, both in new systems sold and as an upgrade to existing systems already in use in cytogenetics labs, thus commercializing the technology quickly.