NANO-HYDROXYAPATITE IN BIOPOLYMERIC SCAFFOLDS FOR BONE

描述：许多新的聚合物系统正在开发，以适应 生物材料需要骨重建。然而，尽管取得了重大进展， 新的组织工程技术的发展，以更好地近似 复杂组织等同物的复杂三维性质，它具有 仍然是开发临床适用的骨替代物的挑战 至少部分是由于难以播种相对厚的材料， 支架与细胞（>1 mm），并保持细胞活力， 体外和体内的时间段。这是这笔赠款的目的 应用于开发坚固的生物活性生物聚合物骨移植材料 使用纳米颗粒羟基磷灰石（“纳米-HA”）。总体目标是 将纳米颗粒技术应用于生物聚合物支架， 支持细胞穿透并保持骨机械稳定性的能力 修复网站第一期工程将研究以下项目的可行性： 增强骨的组织反应以及骨的机械完整性 使用由以下材料制成的支架修复或填充缺陷 通过聚（丙烯）交联制备的生物聚合物泡沫 乙二醇-共-富马酸）（PPF）。 拟定商业应用： 骨是仅次于血液的第二大植入材料。 有超过 美国每年有45万例骨移植手术（全球220万例）， 4亿到6亿美元的潜力。 新的组织工程骨替代材料将 在这个不断增长的市场中找到一个利基。

DESCRIPTION: Many new polymer systems are being developed to accommodate biomaterial needs bone reconstruction. However, despite significant advances in the development of newer tissue engineering technologies to better approximate the complex three-dimensional nature of complex tissue equivalents, it has remained a challenge to develop clinically applicable bone replacement materials at least in part due to the difficulty to seed relatively thick scaffolds with cells (>1 mm) and to maintain cell viability for prolonged periods of time in vitro as well as in vivo. It is the purpose of this grant application to develop strong, bioactive biopolymeric bone graft materials using nanoparticulate hydroxyapatite ("nano-HA"). The overall objective is to employ nanoparticle technology to biopolymeric scaffolds to improve their ability to support cell penetration and maintain mechanical stability at bony repair sites. This Phase I project will investigate the feasibility of enhancing tissue responses in, as well as the mechanical integrity of, bony defects subject to repair or void filling using scaffold fashioned from a biopolymeric foam made via the crosslinking of poly(propylene glycol-co-fumaric) acid (PPF) in the presence of effervescent filters. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are over 450,000 bone graft procedures annually in the U.S. (2.2 million worldwide) with a market potential of $400 to $600 million. New tissue engineered bone replacement materials would find a niche in this ever growing market.